1012085-24-3Relevant articles and documents
Calcium-catalyzed diastereo- and enantioselective 1,4-addition of glycine derivatives to α,β-unsaturated esters
Kobayashi, Shu,Tsubogo, Tetsu,Saito, Susumu,Yamashita, Yasuhiro
supporting information; experimental part, p. 807 - 809 (2009/04/06)
The first highly diastereo- and enantioselective catalytic asymmetric 1,4-addition reactions of a glycine Schiff base to β-substituted α, β-unsaturated esters have been developed. The reaction pathway was successfully controlled, and the desired 1,4-addition products were exclusively obtained with high enantioselectivities. The product obtained was converted to a 3-substituted glutamic acid derivative by acid hydrolysis.