101219-31-2

Basic information

• Product Name: 5-chloro-2-phenylbenzo[b]thiophene
• Synonyms: 5-chloro-2-phenylbenzo[b]thiophene
• CAS NO: 101219-31-2
• Molecular Weight: 244.744
• Mol File: 101219-31-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 5-chloro-2-phenylbenzo[b]thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-phenylbenzo[b]thiophene(101219-31-2)
• EPA Substance Registry System: 5-chloro-2-phenylbenzo[b]thiophene(101219-31-2)

Safety Data

• Hazardous Substances Data: 101219-31-2(Hazardous Substances Data)

Upstream product

• 62835-70-5 4-chloro-2-iodothiophenol 
• 536-74-3 phenylacetylene 
• 16423-54-4 2-amino-4-chlorophenyl methyl sulphide 
• 1004-00-8 4-chloro-2-aminobenzenethiol 
• 20532-33-6 5-chlorobenzothiophene 
• 591-50-4 iodobenzene 
• 174265-12-4 2-bromo-5-chlorobenzaldehyde 
• 101-41-7 benzeneacetic acid methyl ester 

Relevant articles and documents

Metalated Porous Phenanthroline-Based Polymers as Efficient Heterogeneous Catalysts for Regioselective C?H Activation of Heteroarenes

Direct C?H bond activation of heterocycles as a step-economical and environmentally friendly approach to build the heterobiaryls motifs is highly attractive, but it still has a challenge to design and prepare a cheap and regioselective heterogeneous catal

Method for synthesizing benzothiophene derivative by catalysis of dihalogenated aromatics by copper

The invention discloses a method for synthesizing a benzothiophene derivative by catalysis of dihalogenated aromatics by copper. According to the invention, a catalyst cuprous iodide with a catalysisamount, a ligand 8-hydroxyquinoline, an auxiliary catalyst cesium carbonate and 1-bromine-2-iodobenzene or its derivative, sulfur powder, and phenylacetylene or its derivative are added in a flask andsubjected to a reaction in pure water at certain temperature, after a certain time, vacuum concentration is carried out, and a product is purified through column chromatography. The method has the advantages of novel raw material and simple operation, and can be used for efficiently preparing the benzothiophene derivative. Compared with the prior art, the method has the advantages of mild reaction condition, simple operation, high yield, safety, low cost, and environmental protection.

Synthesis of 2-substituted benzo[b]thiophene via a Pd-catalyzed coupling of 2-iodothiophenol with phenylacetylene

A Pd(ii)-catalyzed Sonogashira type cross-coupling reaction between 2-iodothiophenol and phenylacetylene has been developed. A series of 2-substituted benzo[b]thiophenes were obtained in moderate to good yield (up to 87%). The application of this method was demonstrated by the synthesis of 2-(4-(tert-butyl)phenyl)benzo[b]thiophene 1,1-dioxide and (4-methoxyphenyl)(2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)methanone, which exhibit a fluorescence quantum yield of up to 1 and can be used as a cannabinoid receptor ligand, respectively.