101226-37-3

Basic information

• Product Name: 1-(2-Trimethylsilylethoxymethyl)-1H-benzoimidazole
• Synonyms: 1-(2-Trimethylsilylethoxymethyl)-1H-benzoimidazole
• CAS NO: 101226-37-3
• Molecular Weight: 248.4
• Mol File: 101226-37-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(2-Trimethylsilylethoxymethyl)-1H-benzoimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Trimethylsilylethoxymethyl)-1H-benzoimidazole(101226-37-3)
• EPA Substance Registry System: 1-(2-Trimethylsilylethoxymethyl)-1H-benzoimidazole(101226-37-3)

Safety Data

• Hazardous Substances Data: 101226-37-3(Hazardous Substances Data)

Usage

Chemical class

Benzoimidazole derivative

Functional groups

Trimethylsilyl group, ethoxymethyl side chain

Application

Organic synthesis and pharmaceutical research

Use as a building block

Synthesis of biologically active compounds

Potential therapeutic properties

Antitumor, antimicrobial, and antiviral

Role of trimethylsilyl group

Protective group in organic synthesis, enhances stability and reactivity for specific reactions

Upstream product

• 51-17-2 benzoimidazole 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 

Downstream Products

• 1357142-85-8 [4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl](1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-2-yl)methanone 
• 220753-45-7 2-Phenyl-1-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-2-yl]-ethanone 

Relevant articles and documents

methyl (SEM) as a Novel and Effective Imidazole and Fused Aromatic Imidazole Protecting Group

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SHIP1 MODULATORS AND METHODS RELATED THERETO

Compounds of formula (I): where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of formula (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists

Novel 3-substituted 8-aza-bicyclo[3.2.1]octanes (commonly known as “tropanes”) substituted in the 8-position are effective as NMDA NR2B antagonists useful for relieving pain.