1012342-23-2Relevant articles and documents
Catalytic asymmetric protonation of silyl ketene imines
Guin, Joyram,Varseev, Georgy,List, Benjamin
supporting information, p. 2100 - 2103 (2013/03/28)
An efficient catalytic and highly enantioselective protonation of silyl ketene imines is described. The reaction is catalyzed by the chiral phosphoric acids TRIP or STRIP in the presence of a stoichiometric amount of methanol as the proton source and silyl acceptor. A variety of substituted racemic silyl ketene imines have been transformed into highly enantioenriched nitriles.