101255-84-9

Basic information

• Product Name: 1-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]PROPAN-1-ONE
• Synonyms: IVK/1002323;Oprea1_240049;1-[4-(2-piperidinoethoxy)phenyl]propan-1-one;1-[4-[2-(1-piperidyl)ethoxy]phenyl]propan-1-one;1-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]PROPAN-1-ONE;1-Propanone, 1-[4-[2-(1-piperidinyl)ethoxy]phenyl]-
• CAS NO: 101255-84-9
• Molecular Formula: C₁₆H₂₃NO₂
• Molecular Weight: 261.36
• Mol File: 101255-84-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 397.8±22.0 °C(Predicted)
• Appearance: /
• Density: 1.039±0.06 g/cm3(Predicted)
• PKA: 8.53±0.10(Predicted)
• CAS DataBase Reference: 1-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]PROPAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]PROPAN-1-ONE(101255-84-9)
• EPA Substance Registry System: 1-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]PROPAN-1-ONE(101255-84-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 101255-84-9(Hazardous Substances Data)

Usage

Description

1-(4-(2-(piperidin-1-yl)ethoxy)phenyl)propan-1-one, also known as PEPP, is a complex chemical compound belonging to the class of ketones. It features a phenyl ring with a piperidine group attached to it, connected via an ethoxy bridge, and the entire structure is linked to a propan-1-one group. PEPP's unique molecular structure and potential pharmacological properties make it a promising candidate for applications in medicinal chemistry and drug development. However, further research is necessary to fully comprehend its biological and chemical properties.

Uses

Used in Pharmaceutical Industry:
1-(4-(2-(piperidin-1-yl)ethoxy)phenyl)propan-1-one is used as a potential active pharmaceutical ingredient for the development of new drugs due to its unique molecular structure and potential pharmacological properties.
Used in Medicinal Chemistry Research:
1-(4-(2-(piperidin-1-yl)ethoxy)phenyl)propan-1-one is used as a compound of interest in medicinal chemistry research to explore its potential interactions with biological targets and its efficacy in treating various diseases.
Used in Drug Development:
1-(4-(2-(piperidin-1-yl)ethoxy)phenyl)propan-1-one is used as a starting point for designing and synthesizing new drug candidates, leveraging its unique structure to target specific biological pathways or receptors.
Note: The specific application reasons for PEPP are not provided in the materials, so the uses listed above are general applications based on its classification as a chemical compound with potential in medicinal chemistry and drug development. Further research would be needed to identify specific therapeutic applications and reasons for its use.

Upstream product

• 1932-03-2 2-(piperidin-4-yl)ethyl chloride 
• 70-70-2 4-hydroxypropiophenone 
• 2008-75-5 N-chloroethylpiperidine hydrochloride 

Downstream Products

• 1361968-16-2 C₂₃H₂₆N₂O₂ 

Relevant articles and documents

Compound and applications of compound in preparation of anti-hepatitis C virus drugs

The present invention discloses a compound and applications of the compound in preparation of anti-hepatitis C virus drugs, wherein the structure formula of the compound is represented by a formula I or II, and the compound represented by the formula I or compound represented by the formula II can be subjected to drug combination with other anti-virus drugs such as interferon (PEG IFN-[alpha]), ribavirin (RBV), boceprevir, telaprevir, simeprevir, sofosbuvir, daclatasvir and the like t prepare anti-HCV products and other anti-virus infection products. According to the present invention, the compound has rich functional group diversity and modificability, and the product is relatively easy to separate and purify; the compounds can well inhibit HCV and other viruses, are obtained through phenotype screening, have different antiviral mechanisms, have extremely novel and innovated structures in the anti-virus field, and are not reported in the prior art; and the compound of the present invention has broad development and application prospect.

Flexible estrogen receptor modulators: Design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells

Although many series of estrogen receptor antagonists continue to be produced, the majority are direct structural analogues of existing modulators. To examine the tolerance of the estrogen receptor toward flexible ligands, a series of novel flexible estrogen receptor antagonists were prepared and their antiproliferative effects on human MCF-7 breast tumor cells investigated. Each of these compounds deviated from the traditional triphenylethylene backbone associated with common tamoxifen analogues through the introduction of a flexible methylene (benzylic) spacing group between one of the aryl rings and the ethylene group and through variations in the basic side chain moiety. The compounds prepared, when assayed in conjunction with a tamoxifen standard, demonstrated high potency in antiproliferative assays against an MCF-7 human breast cancer cell line with low cytotoxicity and high binding affinity. A computational study was undertaken to investigate the compounds' potential interactions with specific residues within the human estrogen receptor α ligand-binding domain (ER-LBD), predicting these compounds bind in an antiestrogenic fashion within the ER-LBD and interact with those important residues previously identified in the structures of ER-LBD agonist/antagonist cocrystals. These compounds further illustrate the eclectic nature of the estrogen receptor in terms of ligand flexibility tolerance.