101268-52-4

Basic information

• Product Name: 2,2-diethoxyethyl benzoate
• Synonyms: ethanol, 2,2-diethoxy-, benzoate
• CAS NO: 101268-52-4
• Molecular Formula: C₁₃H₁₈O₄
• Molecular Weight: 238.2796
• Mol File: 101268-52-4.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 272.9°C at 760 mmHg
• Flash Point: 112.2°C
• Density: 1.068g/cm³
• Vapor Pressure: 0.00593mmHg at 25°C
• Refractive Index: 1.491
• CAS DataBase Reference: 2,2-diethoxyethyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-diethoxyethyl benzoate(101268-52-4)
• EPA Substance Registry System: 2,2-diethoxyethyl benzoate(101268-52-4)

Safety Data

• Hazardous Substances Data: 101268-52-4(Hazardous Substances Data)

Upstream product

• 532-32-1 sodium benzoate 
• 17157-48-1 bromoacetaldehyde 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 582-25-2 Potassium benzoate 
• 621-62-5 chloroacetaldehyde diethyl acetal 
• 65-85-0 benzoic acid 
• 98-88-4 benzoyl chloride 
• 621-63-6 glycoaldehyde diethyl acetal 

Downstream Products

• 143338-44-7 2-[(phenylcarbonyloxy)methyl]-1,3-oxathiolane 

Relevant articles and documents

Diastereoselective synthesis of (1,3-Dioxan-4-yl)pyrimidine and purin nucleoside analogues

(1,3-Dioxan-4-yl)-substituted nucleoside analogues, higher homologues of antiviral and anticancer 1,3-dioxolanes, were prepared from the key intermediate (4-acetoxy-1,3-dioxan- 2-yl)methyl benzoate and silylated bases. Glycosylation, carried out under Vorbrüggen conditions in the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) as a catalyst, afforded the desired compounds with high stereoselecti- vity and regioselectivity, with only the desired β-anomeric N- 1 pyrimidine and N-9 purin nucleosides being obtained. 1H NMR experiments established that the β-anomers were diequatorial, and this assignment was confirmed by singlecrystal X-ray diffraction. Despite their structural similarities with natural nucleosides, none of the synthesized nucleosides showed antiviral activity.

Preparation of renieramycin left-half model compounds

Model compounds of the left-half of renieramycins, which are anticancer marine natural products having an α-aminonitrile functionality, were prepared from phenylalanine derivatives. The key step of the transformation is the stereospecific construction of 1,3-cis stereochemistry via an exomethylene intermediate. The stereoselective α-aminonitrile formation under kinetically controlled conditions is also discussed. The initial cytotoxicity profiles are presented.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Diversity-oriented synthesis of cyclopropyl peptides from Ugi-derived dehydroalanines

A three-step synthesis of cyclopropyl peptides is reported. The protocol involves a consecutive Ugi-4CR/elimination reaction to prepare dehydroalanines followed by a Corey-Chaykovsky cyclopropanation reaction. Peptide-like molecules that resemble some pharmacologically active compounds with a variety of substituents in the cyclopropane ring were prepared. When (2-ethoxy-2-oxoethyl) dimethyl sulfonium ylide was used the reaction exclusively gives the cis-diastereoisomer cyclopropanes in good yields from readily prepared starting materials. A collection of 26 highly substituted cyclopropyl peptides were obtained.