10129-16-5

Basic information

• Product Name: 2-[[2-(benzoylamino)benzoyl]amino]-benzoic acid
• Synonyms: 2-[[2-(benzoylamino)benzoyl]amino]-benzoic acid
• CAS NO: 10129-16-5
• Molecular Weight: 360.369
• Mol File: 10129-16-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-[[2-(benzoylamino)benzoyl]amino]-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[[2-(benzoylamino)benzoyl]amino]-benzoic acid(10129-16-5)
• EPA Substance Registry System: 2-[[2-(benzoylamino)benzoyl]amino]-benzoic acid(10129-16-5)

Safety Data

• Hazardous Substances Data: 10129-16-5(Hazardous Substances Data)

Upstream product

• 612-34-0 N-anthraniloyl-anthranilic acid 
• 98-88-4 benzoyl chloride 
• 150256-42-1 2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)benzoic acid 
• 228581-79-1 ethyl 2-(2-aminobenzoylamino)-benzoate 
• 326901-33-1 ethyl 2-(2-nitrobenzoylamino)-benzoate 
• 552-16-9 ortho-nitrobenzoic acid 
• 610-14-0 2-nitrobenzyl chloride 

Relevant articles and documents

Isolation, Structure Elucidation, Semi-Synthesis, and Structural Modification of C19-Diterpenoid Alkaloids fromAconitum apetalumand Their Neuroprotective Activities

Five new aconitine-type C19-diterpenoid alkaloids, apetalrines A-E (1-5), were isolated fromAconitum apetalum. Their structures were determined by analysis of 1D and 2D NMR, IR, and HRESIMS data. Semisynthesis of apetalrine B (2) from its parent compound aconorine was achieved to confirm the structure proposed. Twenty derivatives of2(11a-11l12a12b12d12e12j12k12m12n) were synthesized via a unified approach relying on simple coupling reactions. The evaluation of neuroprotective effects of compounds (1-511b11c11f-11i12a12b12d12e12k12m12n) with low cytotoxicity revealed compound2to exhibit good neuroprotective effects in H2O2-treated SH-SY5Y cells at a concentration of 50 μM. A series of studies using flow cytometry, staining, and Western blotting on2indicated that its neuroprotective effects may arise from inhibiting cell apoptosis.

Synthesis, biological evaluation, and structure-activity relationships of 2-[2-(benzoylamino)benzoylamino]benzoic acid analogues as inhibitors of adenovirus replication

2-[2-Benzoylamino)benzoylamino]benzoic acid (1) was previously identified as a potent and nontoxic antiadenoviral compound (Antimicrob. Agents Chemother. 2010, 54, 3871). Here, the potency of 1 was improved over three generations of compounds. We found that the ortho, ortho substituent pattern and the presence of the carboxylic acid of 1 are favorable for this class of compounds and that the direction of the amide bonds (as in 1) is obligatory. Some variability in the N-terminal moiety was tolerated, but benzamides appear to be preferred. The substituents on the middle and C-terminal rings were varied, resulting in two potent inhibitors, 35g and 35j, with EC50 = 0.6 μM and low cell toxicity.