101301-19-3Relevant articles and documents
A Simple Method for Amide Formation from Protected Amino Acids and Peptides
Chen, Shui-Tein,Wu, Shih-Hsiung,Wang, Kung-Tsung
, p. 37 - 38 (2007/10/02)
Amide formation from protected amino acids and peptides is directly and simply achieved by using 1-hydroxybenzotriazole as activating agent and treating the intermediate O-(benzotriazol-1-yl) derivative ("active ester") in situ with 25percent ammonium hydroxide solution.