101328-84-1 Usage
Description
(S)-3(2h)-Pyridazinone, 6-(4-Aminophenyl)-4,5-Dihydro-5-Methylis a chemical compound that serves as an intermediate in the synthesis of various pharmaceutical agents. It is characterized by its unique molecular structure, which includes a pyridazinone ring, an aminophenyl group, and a methyl substituent. (S)-3(2h)-Pyridazinone, 6-(4-Aminophenyl)-4,5-Dihydro-5-Methylplays a crucial role in the development of bioactive molecules with potential therapeutic applications.
Uses
Used in Pharmaceutical Industry:
(S)-3(2h)-Pyridazinone, 6-(4-Aminophenyl)-4,5-Dihydro-5-Methylis used as a key intermediate in the synthesis of Dextrosimendan (D299550), an isomer and impurity of Levosimendan (L378000). Levosimendan is a bioactive enantiomer of Simendan (S466000) and possesses positive inotropic and vasodilating activities, making it a valuable compound in the development of cardiovascular medications.
In the synthesis process, (S)-3(2h)-Pyridazinone, 6-(4-Aminophenyl)-4,5-Dihydro-5-Methylcontributes to the formation of the desired pharmacological agents, which can be further optimized for their therapeutic properties. Its role as an intermediate highlights the importance of this compound in the advancement of novel drug candidates for the treatment of various medical conditions, particularly those related to cardiovascular health.
Check Digit Verification of cas no
The CAS Registry Mumber 101328-84-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,3,2 and 8 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 101328-84:
(8*1)+(7*0)+(6*1)+(5*3)+(4*2)+(3*8)+(2*8)+(1*4)=81
81 % 10 = 1
So 101328-84-1 is a valid CAS Registry Number.
101328-84-1Relevant articles and documents
Carbene-catalyzed enantioselective annulation of dinucleophilic hydrazones and bromoenals for access to aryl-dihydropyridazinones and related drugs
Chi, Yonggui Robin,Li, Xiangyang,Maiti, Rakesh,Mondal, Bivas,Tian, Weiyi,Xu, Jun,Yan, Jia-Lei,Yang, Xing
, p. 8778 - 8783 (2021)
4,5-Dihydropyridazinones bearing an aryl substituent at the C6-position are important motifs in drug molecules. Herein, we developed an efficient protocol to access aryl-dihydropyridazinone moleculesviacarbene-catalyzed asymmetric annulation between dinuc
DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS
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Page/Page column 221; 222, (2018/05/27)
Compounds of formula (I) which are nicotinamide phosphoribosyltransferase (NAMPT) inhibitors and their use for the treatment of hyperproloferative diseases and/or disorders responsive to induction of cell death.
Synthesis and anti-congestive heart failure activity of novel levosimendan analogues
Wang, Lisheng,Zhou, Hongxiang,Yang, Bin,Chen, Zhigang,Yang, Hua
, p. 287 - 292 (2012/06/05)
A series of levosimendan analogues were designed and synthesized, employing the Friedel-Crafts reaction, hydrolysis, and cyclization from the key intermediate compound R(-)-6-(4-aminophenyl)-5-methyl-4, 5-dihydro-3(2H)- pyridazinone, which was obtained from the starting material, acetanilide. These compounds, except 1b, exhibited potent anti-congestive heart failure activities, especially the compounds 1e and 1k, which showed more effective action than levosimendan. Springer Science+Business Media, LLC 2010.
