101382-55-2Relevant articles and documents
Design and Evaluation of Quinolone Derivatives as Potent Inhibitors of Wild-type TTR and V30M TTR Amyloidogenesis
Jung, Jiman,Lee, Namgeol,Park, Hwanggue,Park, Sung Jean,Choi, Sungwook
, p. 719 - 722 (2015)
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Cysteine driven decomposition and quenching of a fluorescent metalloreceptor: Optical detection and mechanistic insight
Asthana, Sharad Kumar,Kumar, Ajit
, (2022/01/13)
We herein devised a fluorescent metalloreceptor (ZNQ) for selective recognition of cysteine (Cys) via fluorescence suppression. The metalloreceptor, ZNQ is a Zn2+ complex of Quinolineimines based ligand (CMO). The surgical action of Cys over metalloreceptor (ZNQ) finishes in three steps viz. demetallation, hydrolysis of schiff base (CMO) i.e. ligand itself and finally cyclization of aldehyde. Interestingly this type of synergistic mechanistic approach have never been reported in the literature for the detection of any thiols. The structure of metalloreceptor ZNQ was confirmed by single crystal X-ray diffraction and its interaction with Cys have been explored through various spectroscopic studies. The bioimaging of Zn2+ and Cys were also carried out in the living HeLa cell.
BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS
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, (2017/04/04)
The present disclosure provides bicyclic heterocyclic derivatives of formula (I), which may be therapeutically useful, more particularly as bromodomain inhibitors; (I), in which R1, R2, R3, R4, L1, L2, Cy1, Cy2, X, n, and dotted line have the same meaning given in the specification, and pharmaceutically acceptable salts or pharmaceutically acceptable stereoisomers thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in diseases or disorders associated as bromodomain inhibitors. The present disclosure also provides preparation of compounds and pharmaceutical formulations comprising at least one of bicyclic heterocyclic derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent, or excipient.
