10144-64-6Relevant articles and documents
Synthesis of [5-isoleucine, 8-alanine]-angiotensin II by the solution method synthesis and the solid-phase method synthesis.
Park et al.
, p. 3458,3461 (1967)
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Relaxing substrate specificity in antibody-catalyzed reactions: Enantioselective hydrolysis of N-Cbz-amino acid esters
Tanaka, Fujie,Kinoshita, Keiko,Tanimura, Ryuji,Fujii, Ikuo
, p. 2332 - 2339 (2007/10/03)
For a catalytic antibody to be generally useful for organic synthetic chemistry, it must be able to accept a broad range of substrates, yet retain high selectivity. In this work, we propose a hapten design to endow antibody catalysts with two opposing qualities, such as high enantioselectivity and broad substrate specificity. Racemic hapten 2 induced two separate classes of catalytic antibodies to hydrolyze either the L- or D-isomers of N-Cbz-amino acid esters 1. In the kinetic resolution of racemic ester 9, antibodies 7G12 and 3G2 gave 96% ee of L-10 and 94% ee of D-10, respectively. In addition, antibody 7G12 displayed broad substrate specificity, hydrolyzing the L-esters of Ala (1a), Leu (1b), Norleu (1c), Met (1d), Phe (1e), Val (1f), and phenylglycine (1g) with high enantioselectivity. Antibody 3G2 also hydrolyzed the D-isomers of these esters without sacrificing the enantioselectivity. This observation suggests that the use of haptens that fit snugly into the antigen-combining site, and leave the linker moiety outside, is an effective approach for the generation of catalytic antibodies with high selectivity and broad substrate applicability.
CONVENIENT ONE-POT ESTERIFICATION OF N-PROTECTED AMINOACIDS VIA ISOPROPENYL CHLOROFORMATE ACTIVATION.
Jouin, P.,Castro, B.,Zeggaf, C.,Pantaloni, A.,Senet, J.P.,et. al
, p. 1661 - 1664 (2007/10/02)
Activation of N-protected aminoacids by isopropenyl chloroformate leads to esters of primary, secondary and tertiary alcohols with 4-dimethylamino-pyridine as catalyst.
