1014980-12-1

Basic information

• Product Name: 1-(2-chlorophenyl)-4-phenylbutane-1,4-dione
• CAS NO: 1014980-12-1
• Molecular Weight: 272.731
• Mol File: 1014980-12-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2-chlorophenyl)-4-phenylbutane-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chlorophenyl)-4-phenylbutane-1,4-dione(1014980-12-1)
• EPA Substance Registry System: 1-(2-chlorophenyl)-4-phenylbutane-1,4-dione(1014980-12-1)

Safety Data

• Hazardous Substances Data: 1014980-12-1(Hazardous Substances Data)

Upstream product

• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 70-11-1 α-bromoacetophenone 
• 532-27-4 1-chloroacetophenone 

Downstream Products

• 1014981-31-7 C₁₈H₁₄ClNO₂ 

Relevant articles and documents

Mild Homologation of Esters through Continuous Flow Chloroacetate Claisen Reactions

The selective chloromethylenation of functionalized esters using chloroacetic acid (CA) and LiHMDS (HMDS=hexamethyldisilazide) in a continuous-flow setup is reported. This Claisen homologation is for the first time extended to bis-chloromethylenation using dichloroacetic acid (DCA), thus giving access to under-explored α,α′-bis-chloroketones. The use of flow conditions enables efficient generation and reaction of the unstable chloroacetate dianion intermediates, leading to unprecedented mild and scalable reaction conditions at an economical reagent stoichiometry (?10 °C, 1 min, 1.0–2.4 equiv dianion). The clean reaction profiles allow subsequent use of the unpurified crude products, which is demonstrated in the synthesis of various heterocycles of broad interest. Furthermore, we report a novel, catalyst-free substitution of the obtained monochloro ketone products with (hetero)aryl zinc enolates to give valuable 1,4-diketones.