101561-61-9

Basic information

• Product Name: N-benzylidene-1-(thiophen-2-yl)methanamine
• Synonyms: N-benzylidene-1-(thiophen-2-yl)methanamine
• CAS NO: 101561-61-9
• Molecular Weight: 201.292
• Mol File: 101561-61-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-benzylidene-1-(thiophen-2-yl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzylidene-1-(thiophen-2-yl)methanamine(101561-61-9)
• EPA Substance Registry System: N-benzylidene-1-(thiophen-2-yl)methanamine(101561-61-9)

Safety Data

• Hazardous Substances Data: 101561-61-9(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 4595-96-4 N-(thiophen-2-yl-methyl)benzamide 
• 27757-85-3 2-Aminomethylthiophene 
• 100-52-7 benzaldehyde 
• 94807-34-8 1,1,1,3,3,3-Hexamethyl-2-thiophen-2-ylmethyl-disilazane 

Downstream Products

• 1312718-57-2 C₂₀H₂₄N₂O₂S 
• 1312718-60-7 C₁₃H₁₂ClNOS 
• 73325-61-8 N-benzyl-1-(thiophen-2-yl)methanamine 

Relevant articles and documents

A CONVENIENT SYNTHETIC METHOD FOR SCHIFF BASES. THE TRIMETHYLSILYL TRIFLUOROMETHANESULFONATE-CATALYZED REACTION OF N,N-BIS(TRIMETHYLSILYL)AMINES WITH ALDEHYDES AND KETONES

N,N-Bis(trimethylsilyl)amines react with aldehydes or ketones in the presence of trimethylsilyl trifluoromethanesulfonate to give Schiff bases in high yields.In situ utilization of the reaction solution as the Schiff base is also demonstrated.

Enantioselective Reductive Cyanation and Phosphonylation of Secondary Amides by Iridium and Chiral Thiourea Sequential Catalysis

The combination of transition-metal catalysis and organocatalysis increasingly offers chemists opportunities to realize diverse unprecedented chemical transformations. By combining iridium with chiral thiourea catalysis, direct enantioselective reductive cyanation and phosphonylation of secondary amides have been accomplished for the first time for the synthesis of enantioenriched chiral α-aminonitriles and α-aminophosphonates. The protocol is highly efficient and enantioselective, providing a novel route to the synthesis of optically active α-functionalized amines from the simple, readily available feedstocks. In addition, the reactions are scalable and the thiourea catalyst can be recycled and reused.

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists

Novel quaternary ammonium derivatives of N,N-disubstituted (3R)-quinuclidinyl carbamates have been identified as potent M3 muscarinic antagonists with long duration of action in an in vivo model of bronchoconstriction. These compounds have also presented a high level of metabolic transformation (human liver microsomes). The synthesis, structure-activity relationships and biological evaluation of these compounds are reported.