10157-97-8

Basic information

• Product Name: 4-{[(3beta,5alpha,6beta)-5,6-dihydroxycholestan-3-yl]oxy}-4-oxobutanoic acid
• Synonyms: CT-5;5α-Cholestane-3β,5,6β-triol 3-hydrogen succinate;Cholestane-3,5,6-triol,3-(hydrogen butanedioate)
• CAS NO: 10157-97-8
• Molecular Formula: C₃₁H₅₂O₆
• Molecular Weight: 520.741
• Mol File: 10157-97-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 615.2°C at 760 mmHg
• Flash Point: 188.2°C
• Density: 1.13g/cm³
• Vapor Pressure: 1.05E-17mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: 4-{[(3beta,5alpha,6beta)-5,6-dihydroxycholestan-3-yl]oxy}-4-oxobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{[(3beta,5alpha,6beta)-5,6-dihydroxycholestan-3-yl]oxy}-4-oxobutanoic acid(10157-97-8)
• EPA Substance Registry System: 4-{[(3beta,5alpha,6beta)-5,6-dihydroxycholestan-3-yl]oxy}-4-oxobutanoic acid(10157-97-8)

Safety Data

• Hazardous Substances Data: 10157-97-8(Hazardous Substances Data)

Upstream product

• 1510-21-0 cholesteryl hemisuccinate 

Relevant articles and documents

Sterols as anticancer agents: Synthesis of ring-B oxygenated steroids, cytotoxic profile, and comprehensive SAR analysis

The cytotoxicity of oxysterols was systematically studied in tumor and normal cells. Synthetic strategies to prepare this library included oxidations at ring B and a new method to yield 6β-hemiphthalates directly from Δ5-steroids. Most oxysterols were cytotoxic and showed selectivity toward cancer cells, LAMA-84 cells (leukemia) being particularly sensitive to 4, 8, 22, and 27 (IC50 5.6 μM). The structural requirements to induce selective toxicity are discussed to shed light on the development of new anticancer drugs.