1016-50-8

Basic information

• Product Name: 1-(2-phenylethyl)pyrrolidine-2,5-dione
• Synonyms: 1-(2-Phenylethyl)pyrrolidine-2,5-dione; 2,5-pyrrolidinedione, 1-(2-phenylethyl)-
• CAS NO: 1016-50-8
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.2371
• Mol File: 1016-50-8.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 388.8°C at 760 mmHg
• Flash Point: 184.5°C
• Density: 1.188g/cm³
• Vapor Pressure: 2.98E-06mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 1-(2-phenylethyl)pyrrolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-phenylethyl)pyrrolidine-2,5-dione(1016-50-8)
• EPA Substance Registry System: 1-(2-phenylethyl)pyrrolidine-2,5-dione(1016-50-8)

Safety Data

• Hazardous Substances Data: 1016-50-8(Hazardous Substances Data)

Usage

General Description

1-(2-phenylethyl)pyrrolidine-2,5-dione is a chemical compound that belongs to the class of pyrrolidine-2,5-diones. It is commonly used as a core structure for the synthesis of various pharmaceutical and biologically active compounds. 1-(2-phenylethyl)pyrrolidine-2,5-dione is known for its potential biological activities, such as anticonvulsant, psychotropic, and sedative effects. It has also been studied for its potential use in the treatment of neurological disorders and psychiatric conditions. The chemical structure of 1-(2-phenylethyl)pyrrolidine-2,5-dione makes it an important molecule in medicinal chemistry, and its potential applications continue to be explored in research and drug development.

Upstream product

• 123-91-1 1,4-dioxane 
• 110-15-6 succinic acid 
• 64-04-0 phenethylamine 
• 123-56-8 Succinimide 
• 103-63-9 1-phenyl-2-bromoethane 
• 128-09-6 N-chloro-succinimide 
• 501-52-0 3-Phenylpropionic acid 
• 516-12-1 N-iodo-succinimide 
• 110-63-4 Butane-1,4-diol 
• 4796-01-4 N-2-phenylethylmaleamic acid 
• 6943-90-4 N-phenethylmaleimide 
• 108-30-5 succinic acid anhydride 
• 123-25-1 succinic acid diethyl ester 
• 1083-55-2 N-(2-phenylethyl)succinamic acid 

Downstream Products

• 39662-49-2 5-hydroxy-1-phenethyl-pyrrolidin-2-one 
• 7530-17-8 1-(2-cyclohexyl-ethyl)-pyrrolidine 
• 58880-18-5 4-[bis-(2-chloro-ethyl)-amino]-phenethylamine 
• 860428-66-6 N-{4-[bis-(2-chloro-ethyl)-amino]-phenethyl}-succinimide 
• 857753-98-1 N-{4-[bis-(2-hydroxy-ethyl)-amino]-phenethyl}-succinimide 
• 66951-59-5 N-(4-amino-phenethyl)-succinimide 
• 123-56-8 Succinimide 
• 81416-16-2 6-phenylhexahydroazepine-2,5-dione 
• 191864-36-5 N-<2-(4-nitrophenyl)ethyl>succinimide 
• 856353-96-3 1-(2′-cyclohexylethyl)pyrrolidine-2,5-dione 
• 861035-95-2 1-(2-cyclohexyl-ethyl)-pyrrolidin-2-one 
• 6908-75-4 N-(2-phenylethyl)pyrrolidine 

Relevant articles and documents

Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts

We describe the synthesis of tetrahydroisoquinolines and tetrahydroisoquinolinium salts together with their pharmacological properties at various nicotinic acetylcholine receptors. In general, the compounds were α4β2 nAChR antagonists, with the tetrahydroisoquinolinium salts being more potent than the parent tetrahydroisoquinoline derivatives. The most potent α4β2 antagonist, 6c, exhibited submicromolar binding Ki and functional IC50 values and high selectivity for this receptor over the α4β4 and α3β4 nAChRs. Whereas the (S)-6c enantiomer was essentially inactive at α4β2, (R)-6c was a slightly more potent α4β2 antagonist than the reference β2-nAChR antagonist DHβη. The observation that the α4β2 activity resided exclusively in the (R)-enantiomer was in full agreement with docking studies. Several of tetrahydroisoquinolinium salts also displayed agonist activity at the α7 nAChR. Preliminary in vivo evaluation revealed antidepressant-like effects of both (R)-5c and (R)-6c in the mouse forced swim test, supporting the therapeutic potential of α4β2 nAChR antagonists for this indication.

Versatile and sustainable synthesis of cyclic imides from dicarboxylic acids and amines by Nb2O5 as a base-tolerant heterogeneous lewis acid catalyst

Catalytic condensation of dicarboxylics acid and amines without excess amount of activating reagents is the most atom-efficient but unprecedented synthetic method of cyclic imides. Here we present the first general catalytic method, proceeding selectively and efficiently in the presence of a commercial Nb2O5 as a reusable and base-tolerant heterogeneous Lewis acid catalyst. The method is effective for the direct synthesis of pharmaceutically or industrially important cyclic imides, such as phensuximide, N-hydroxyphthalimide (NHPI), and unsubstituted cyclic imides from dicarboxylic acid or anhydrides with amines, hydroxylamine, or ammonia.

Synthesis of Cyclic Imides by Acceptorless Dehydrogenative Coupling of Diols and Amines Catalyzed by a Manganese Pincer Complex

The first example of base-metal-catalyzed dehydrogenative coupling of diols and amines to form cyclic imides is reported. The reaction is catalyzed by a pincer complex of the earth abundant manganese and forms hydrogen gas as the sole byproduct, making the overall process atom economical and environmentally benign.