1016162-91-6

Basic information

• Product Name: tert-butyl [(1S)-1-{[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]carbonyl}-2-methylpentyl]carbamate
• Synonyms: tert-butyl [(1S)-1-{[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]carbonyl}-2-methylpentyl]carbamate
• CAS NO: 1016162-91-6
• Molecular Weight: 432.604
• Mol File: 1016162-91-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl [(1S)-1-{[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]carbonyl}-2-methylpentyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl [(1S)-1-{[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]carbonyl}-2-methylpentyl]carbamate(1016162-91-6)
• EPA Substance Registry System: tert-butyl [(1S)-1-{[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]carbonyl}-2-methylpentyl]carbamate(1016162-91-6)

Safety Data

• Hazardous Substances Data: 1016162-91-6(Hazardous Substances Data)

Upstream product

• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 
• 149655-33-4 (3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidine 

Downstream Products

• 1187832-28-5 (2S,3S)-1-[(3R,4R)-4-(3-methoxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylpentan-2-amine 

Relevant articles and documents

KAPPA OPIOID RECEPTOR BINDING LIGANDS

Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid

Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1- {[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl) -1,2,3,4-tetrahydro-3-is

In previous structure-activity relationship (SAR) studies, we identified (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1- piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3- isoquinolinecarboxamide (JDTic, 1) as the first poten