10166-05-9

Basic information

• Product Name: Isoquinoline, 4-(phenylmethyl)-
• CAS NO: 10166-05-9
• Molecular Formula: C16H13N
• Molecular Weight: 219.286
• Mol File: 10166-05-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Isoquinoline, 4-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 4-(phenylmethyl)-(10166-05-9)
• EPA Substance Registry System: Isoquinoline, 4-(phenylmethyl)-(10166-05-9)

Safety Data

• Hazardous Substances Data: 10166-05-9(Hazardous Substances Data)

Upstream product

• 13605-92-0 4-(phenylmethyl)-1,2,3,4-tetrahydroisoquinoline 
• 100-53-8 phenylmethanethiol 
• 1532-97-4 4-bromoisoquinoline 
• 943868-13-1 4-benzylsulfanyl-2,3,5,6-tetrafluoropyridine 
• 530-36-9 2-amino-1,2-diphenylethanol 
• 536-74-3 phenylacetylene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 19261-37-1 2-chloro-3-phenyl-propionaldehyde 
• 2446-51-7 N-methoxybenzamide 
• 60813-39-0 4-benzylisoquinolin-1(2H)-one 
• 5415-80-5 2,3-diphenylpropan-1-amine 
• 100-46-9 benzylamine 
• 28272-96-0 2-vinylbenzaldehyde 
• 75802-22-1 1-ethoxyisochromane 

Downstream Products

• 146645-36-5 4-Benzyl-2-trideuteromethyl-1,2,3,4-tetrahydroisochinolin 
• 20335-71-1 3-benzoylisoquinoline 
• 1242188-77-7 2-(p-fluorobenzoyl)-4-benzoyl-1,2-dihydroisoquinaldonitrile 
• 1242188-78-8 4-benzoyl-1-(p-fluorobenzoyl)isoquinoline 
• 1242188-80-2 1-(p-fluorobenzoyl)-4-benzylisoquinoline 
• 1242188-79-9 2-(p-fluorobenzoyl)-4-benzyl-1,2-dihydroisoquinaldonitrile 
• 93405-92-6 4-Benzyl-1,2,3,4-tetrahydro-N-methyl-isochinolin 
• 137439-33-9 4-(4-nitro-benzyl)-isoquinoline 
• 6907-59-1 1-benzylisoquinoline 
• 239-40-7 dibenzo<2,3;7,8>indolizine 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 17054-55-6 4-Benzyl-N-methyl-isochinoliniumiodid 
• 102594-07-0 4-bibenzyl-α-yl-isoquinoline 

Relevant articles and documents

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Synthesis of isoquinolines and pyridines via palladium-catalysed iminoannulation of allenes

Various isoquinolines and pyridines were prepared from aryl- and vinyl halides by a method which involves insertion of an allene into the Pd-C bond and intramolecular nucleophilic attack of the imine.

Microwave-Assisted Palladium-Catalyzed Reductive Cyclization/Ring-Opening/Aromatization Cascade of Oxazolidines to Isoquinolines

An efficient palladium-catalyzed reaction of N-propargyl oxazolidines for the construction of 4-substituted isoquinolines under microwave irradiation is developed. This transformation proceeds through a sequential palladium-catalyzed reductive cyclization/ring-opening/aromatization cascade via C-O and C-N bond cleavages of the oxazolidine ring. The practical value of this method has also been explored by conducting a millimole-scale reaction, as well as by transforming the isoquinoline into a key intermediate for the synthesis of a lamellarin analogue.