1016644-38-4

Basic information

• Product Name: 2-Oxo-2,3-dihydrobenzo[d]oxazol-6-yl-boronic acid
• Synonyms: 2-Oxo-2,3-dihydrobenzo[d]oxazol-6-yl-boronic acid;(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)boronic acid;(2-Oxo-2,3-dihydrobenzo[d]oxazol-6-yl)
• CAS NO: 1016644-38-4
• Molecular Formula: C₇H₆BNO₄
• Molecular Weight: 178.93784
• Mol File: 1016644-38-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Oxo-2,3-dihydrobenzo[d]oxazol-6-yl-boronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxo-2,3-dihydrobenzo[d]oxazol-6-yl-boronic acid(1016644-38-4)
• EPA Substance Registry System: 2-Oxo-2,3-dihydrobenzo[d]oxazol-6-yl-boronic acid(1016644-38-4)

Safety Data

• Hazardous Substances Data: 1016644-38-4(Hazardous Substances Data)

Usage

General Description

2-Oxo-2,3-dihydrobenzo[d]oxazol-6-yl-boronic acid is a chemical compound which belongs to the boronic acids and derivatives group. These chemicals contain a boronoalkanoic acid moiety, which consists of a carbon bearing a carboxylic acid and a boron atom. It is indeed a complex substance of which properties and specific applications are not widely studied or noted down in resources. As often seen with similar boronic acids, it can presumably be used in the fields of pharmaceuticals and drug discovery, especially due to boronic acids' ability to form reversible covalent complexes with sugars, amino acids, and other biological molecules. Currently, specific information on this chemical, including its physical and chemical properties, safety profile, and metabolic pathway, remains limited or not readily available.

Upstream product

• 19932-85-5 6-bromobenzo[d]oxazol-2(3H)-one 
• 13675-18-8 tetrahydroxydiboron 
• 22876-17-1 6-amino-1,3-benzoxazol-2-(3H)-one 
• 14733-73-4 5-bromo-1,3-benzoxazol-2(3H)-one 

Downstream Products

• 1076188-10-7 6-[6-(2-chlorophenyl)-2-oxo-1,2-dihydropyrimidin-4-yl]-1,3-benzoxazol-2(3H)-one 

Relevant articles and documents

Pd- And Ni-Based Systems for the Catalytic Borylation of Aryl (Pseudo)halides with B2(OH)4

Despite recent advancements in metal-catalyzed borylations of aryl (pseudo)halides, there is a continuing need to develop robust methods to access both early-stage and late-stage organoboron intermediates amendable for further functionalization. In particular, the development of general catalytic systems that operate under mild reaction conditions across a broad range of electrophilic partners remains elusive. Herein, we report the development and application of three catalytic systems (two Pd-based and one Ni-based) for the direct borylation of aryl (pseudo)halides using tetrahydroxydiboron (B2(OH)4). For the Pd-based catalyst systems, we have identified general reaction conditions that allow for the sequestration of halide ions through simple precipitation that results in catalyst loadings as low as 0.01 mol % (100 ppm) and reaction temperatures as low as room temperature. We also describe a complementary Ni-based catalyst system that employs simple unligated Ni(II) salts as an inexpensive alternative to the Pd-based systems for the borylation of aryl (pseudo)halides. Extrapolation of all three systems to a one-pot tandem borylation/Suzuki-Miyaura cross-coupling is also demonstrated on advanced intermediates and drug substances.

6-PHENYLPYRIMIDINONES AS PIM MODULATORS

A compound having Formula I or II (Formula I) or (Formula II), or a pharmaceutically acceptable salt thereof, wherein X, Z, R1, R2, R11 and R12 are as defined in the specification; pharmaceutical compositions thereof; and methods of use thereof.