101712-10-1

Basic information

• Product Name: (2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(5-METHYL-2-OXO-4-(1H-1,2,4-TRIAZOL-1-YL)PYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE
• Synonyms: (2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(5-METHYL-2-OXO-4-(1H-1,2,4-TRIAZOL-1-YL)PYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE
• CAS NO: 101712-10-1
• Molecular Formula: C₄₂H₅₀N₇O₇P
• Molecular Weight: 0
• Mol File: 101712-10-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(5-METHYL-2-OXO-4-(1H-1,2,4-TRIAZOL-1-YL)PYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(5-METHYL-2-OXO-4-(1H-1,2,4-TRIAZOL-1-YL)PYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE(101712-10-1)
• EPA Substance Registry System: (2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(5-METHYL-2-OXO-4-(1H-1,2,4-TRIAZOL-1-YL)PYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE(101712-10-1)

Safety Data

• Hazardous Substances Data: 101712-10-1(Hazardous Substances Data)

Usage

Description

(2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(5-METHYL-2-OXO-4-(1H-1,2,4-TRIAZOL-1-YL)PYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE is a complex organic compound utilized in the synthesis of nucleic acid analogs and other biologically active molecules. It features a tetrahydrofuran group, a cyanoethyl group, and a diisopropylphosphoramidite group, among others. Its unique structure and properties make it a valuable tool in the development of new pharmaceuticals and materials.

Uses

Used in Pharmaceutical Industry:
(2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(5-METHYL-2-OXO-4-(1H-1,2,4-TRIAZOL-1-YL)PYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE is used as a key intermediate in the synthesis of nucleic acid analogs for the development of new pharmaceuticals. Its unique structure allows for the creation of molecules with specific biological activities, contributing to the advancement of drug discovery and design.
Used in Chemical Research:
In the field of chemical research, (2R,3S,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(5-METHYL-2-OXO-4-(1H-1,2,4-TRIAZOL-1-YL)PYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3-YL 2-CYANOETHYL DIISOPROPYLPHOSPHORAMIDITE serves as a versatile building block for the creation of complex organic molecules. Its properties enable researchers to explore new chemical reactions and mechanisms, furthering our understanding of organic chemistry and its applications.

Upstream product

• 124482-92-4 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine 
• 360048-15-3 1-(2'-deoxy-5'-O-dimethoxytrityl-β-D-ribofuranosyl)-5-methyl-4-(1,2,4-triazol-1-yl)-2-pyrimidone 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 50-89-5 thymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 98796-51-1 5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] 
• 72741-18-5 tri(1H-1,2,4-triazol-1-yl)phosphine oxide 
• 288-88-0 1,2,4-Triazole 

Relevant articles and documents

Synthesis and triplex-forming properties of oligonucleotides capable of recognizing corresponding DNA duplexes containing four base pairs

A triplex-forming oligonucleotide (TFO) could be a useful molecular tool for gene therapy and specific gene modification. However, unmodified TFOs have two serious drawbacks: low binding affinities and high sequence-dependencies. In this paper, we propose

Synthesis of DNA Containing Modified Bases by Postsynthetic Substitution. Synthesis of Oligomers Containing 4-Substituted Thymine: O4-Alkylthymine, 5-Methylcytosine, N4-(Dimethylamino)-5-methylcytosine, and 4-Thiothymine

A strategy is described for synthesis of oligomers modified in the 4-position of thymine by postsynthetic substitution. 4-Triazolothymine phosphoramidite monomer has been prepared in one step from thymine amidite monomer and incorporated into a 12 mer AGC

Synthesis of Oligodeoxyribonucleotides Containing Oleylamine Moieties

A method for directional introduction of oleylamine residues to any position of oligodeoxyribonucleotides during their automated synthesis was developed. The presence of oleylamine residues in 3′- or 5′-terminal nucleotides was shown to have no effect on

Chemical synthesis of an artificially branched hairpin ribozyme variant with RNA cleavage activity

Due to the development in the field of RNA synthesis over the past decade of years, preparation of RNA oligonucleotides longer than 50 nucleotides is possible today. In this report, we describe the chemical preparation of a branched RNA molecule with RNA cleavage activity consisting of 81 nucleotides. It is derived from the hairpin ribozyme, a small catalytic RNA occurring in nature. The hairpin ribozyme consists of two separately folded domains (loop A and loop B domain), which can be joined in a number of different ways without loss of activity. In the construct presented here, 2′-deoxy-N4-(6- hydroxyhexyl)-5-methylcytidine was introduced to connect the loop B domain with the loop A domain via an artificial branch. The synthesized branched RNA is able to catalyze the cleavage of a number of suitable substrates. Compared with the corresponding non-branched reverse-joined ribozyme it cleaves its substrates only 5-fold slower. Surprisingly, no ligation activity could be detected.