101768-07-4

Basic information

• Product Name: 3-Piperidinemethanol, 1-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester)
• CAS NO: 101768-07-4
• Molecular Formula: C20H25NO5S2
• Molecular Weight: 423.554
• Mol File: 101768-07-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Piperidinemethanol, 1-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Piperidinemethanol, 1-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester)(101768-07-4)
• EPA Substance Registry System: 3-Piperidinemethanol, 1-[(4-methylphenyl)sulfonyl]-, 4-methylbenzenesulfonate (ester)(101768-07-4)

Safety Data

• Hazardous Substances Data: 101768-07-4(Hazardous Substances Data)

Upstream product

• 4606-65-9 3-(hydroxymethy)piperidine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 131912-10-2 α,α-bis(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-3-piperidinepropanenitrile 
• 131911-61-0 1-[3-(4-acetyl-2-methoxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-3-piperidinepropanenitrile 
• 131912-12-4 α,α-bis(4-fluorophenyl)-3-piperidinepropanenitrile 

Relevant articles and documents

β-Hydroxypiperidinecarboxylates: Additions to the chiral pool from bakers' yeast reductions of β-ketopiperidinecarboxylates

Reduction of the piperidine keto esters 16-19 using fermenting bakers' yeast provides high yields of the corresponding hydroxy esters 20, 26, 32 and 37 respectively, exclusively as the cis-diastereoisomers and with good levels (≥80%) of enantiomeric enrichment. The relative stereochemistries of the products were deduced from NMR data while the absolute configurations were determined by degradation to known piperidinemethanol derivatives or, in the case of hydroxy ester 37, by homologation to (R)-3-quinuclidinol 41b.