101774-33-8 Usage
General Description
3-Chloro-4-hydroxyisoquinoline is a chemical compound with the molecular formula C9H6ClNO and a molar mass of 177.60 g/mol. It is a halogenated isoquinoline derivative, which is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. The presence of a chlorine atom and a hydroxyl group in its chemical structure makes it a valuable intermediate in the preparation of various bioactive compounds. 3-Chloro-4-hydroxyisoquinoline is known for its potential as a pharmacological agent, with research indicating its role in the inhibition of certain enzymes and as an anti-inflammatory and anti-microbial agent. Its unique molecular properties and biological activities make it an important target for chemical and pharmaceutical research.
Check Digit Verification of cas no
The CAS Registry Mumber 101774-33-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,7,7 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 101774-33:
(8*1)+(7*0)+(6*1)+(5*7)+(4*7)+(3*4)+(2*3)+(1*3)=98
98 % 10 = 8
So 101774-33-8 is a valid CAS Registry Number.
101774-33-8Relevant articles and documents
Specific chlorination of isoquinolines by a fungal flavin-dependent halogenase
Zeng, Jia,Lytle, Anna K.,Gage, David,Johnson, Sean J.,Zhan, Jixun
, p. 1001 - 1003 (2013)
Rdc2 is the first flavin-dependent halogenase identified from fungi. Based on the reported structure of the bacterial halogenase CmlS, we have built a homology model for Rdc2. The model suggests an open substrate binding site that is capable of binding the natural substrate, monocillin II, and possibly other molecules such as 4-hydroxyisoquinoline (1) and 6-hydroxyisoquinoline (2). In vitro and in vivo halogenation experiments confirmed that 1 and 2 can be halogenated at the position ortho to the hydroxyl group, leading to the synthesis of the chlorinated isoquinolines 1a and 2a, respectively, which further expands the spectrum of identified substrates of Rdc2. This work revealed that Rdc2 is a useful biocatalyst for the synthesis of various halogenated compounds.
