1018125-39-7 Usage
General Description
6-Aminopyrazolo[1,5-a]pyrimidine is a chemical compound with the molecular formula C5H4N4. It is a heterocyclic compound that consists of a pyrazole ring fused to a pyrimidine ring. 6-Aminopyrazolo[1,5-a]pyrimidine is used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has a wide range of potential applications in the field of medicinal chemistry due to its versatile reactivity and the ability to modify its structure to create new compounds with specific properties. Additionally, 6-Aminopyrazolo[1,5-a]pyrimidine is also used as a research tool in the study of biological processes and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 1018125-39-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,8,1,2 and 5 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1018125-39:
(9*1)+(8*0)+(7*1)+(6*8)+(5*1)+(4*2)+(3*5)+(2*3)+(1*9)=107
107 % 10 = 7
So 1018125-39-7 is a valid CAS Registry Number.
1018125-39-7Relevant articles and documents
Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-RafV600E kinase with favorable physicochemical and pharmacokinetic properties
Ren, Li,Laird, Ellen R.,Buckmelter, Alex J.,Dinkel, Victoria,Gloor, Susan L.,Grina, Jonas,Newhouse, Brad,Rasor, Kevin,Hastings, Gregg,Gradl, Stefan N.,Rudolph, Joachim
scheme or table, p. 1165 - 1168 (2012/03/11)
Herein we describe a novel series of ATP competitive B-Raf inhibitors based on the pyrazolo[1,5-a]pyrimidine scaffold. These inhibitors exhibit both excellent cellular potency and striking B-Raf selectivity. Optimization led to the identification of compound 17, a potent, selective and orally available agent with improved physicochemical and pharmacokinetic properties.
