1018676-02-2 Usage
Description
3-[2-(DiMethylaMino)ethyl]-5-[(pyrrolidine-1-yl)sulfonylMethyl]-1H-indol-1-ylMethanol is a complex organic compound characterized by its unique molecular structure. It is an impurity found in Almotriptan (A575201), which is a serotonin 5HT1B/1D-receptor agonist used for the treatment of migraines.
Uses
Used in Pharmaceutical Industry:
3-[2-(DiMethylaMino)ethyl]-5-[(pyrrolidine-1-yl)sulfonylMethyl]-1H-indol-1-ylMethanol is used as an impurity in the production of Almotriptan (A575201) for the treatment of migraines. Its presence in the pharmaceutical compound is significant as it may affect the overall efficacy and safety of the medication.
Application Reason:
The use of 3-[2-(DiMethylaMino)ethyl]-5-[(pyrrolidine-1-yl)sulfonylMethyl]-1H-indol-1-ylMethanol in the pharmaceutical industry is primarily due to its association with Almotriptan, a drug used to treat migraines. As an impurity, it is essential to monitor and control its levels to ensure the safety and effectiveness of the medication.
Check Digit Verification of cas no
The CAS Registry Mumber 1018676-02-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,8,6,7 and 6 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1018676-02:
(9*1)+(8*0)+(7*1)+(6*8)+(5*6)+(4*7)+(3*6)+(2*0)+(1*2)=142
142 % 10 = 2
So 1018676-02-2 is a valid CAS Registry Number.
1018676-02-2Relevant articles and documents
METHOD FOR THE PREPARATION OF HIGH PURITY ALMOTRIPTAN
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Page/Page column 10, (2009/01/24)
A method for the preparation and purification of the substance of formula (I), i.e. 3-[2- (dimethylamino)ethyl]-5-(1-pyrrolidinylsulfonylmethyl)-1H-indole, which comprises (a) conversion of 4-(1-pyrrolidinylsulfonylmethyl)phenylhydrazine of formula (III) by reaction with an organic or inorganic acid to a salt that is insoluble or poorly soluble in water, which is converted to 3-(2-aminoethyl)-5-(1-pyrrolidinylsulfonylmethyl)indole of formula (VII), which is further converted without isolation to a solution of the almotriptan base, which provides a crystalline salt of almotriptan with an organic or inorganic acid; (b) conversion of the salt of almotriptan to the almotriptan base, which separates from the solution in the crystalline form; (c) purification of the almotriptan base by crystallization from an organic solvent.
