1018898-77-5

Basic information

• Product Name: (3aS,5R,6R,6aS)-6-((tert-butyldiMethylsilyl)oxy)-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde
• Synonyms: (3aS,5R,6R,6aS)-6-((tert-butyldiMethylsilyl)oxy)-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde
• CAS NO: 1018898-77-5
• Molecular Formula: C₁₄H₂₆O₅Si
• Molecular Weight: 302.43874
• Mol File: 1018898-77-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3aS,5R,6R,6aS)-6-((tert-butyldiMethylsilyl)oxy)-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (3aS,5R,6R,6aS)-6-((tert-butyldiMethylsilyl)oxy)-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde(1018898-77-5)
• EPA Substance Registry System: (3aS,5R,6R,6aS)-6-((tert-butyldiMethylsilyl)oxy)-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde(1018898-77-5)

Safety Data

• Hazardous Substances Data: 1018898-77-5(Hazardous Substances Data)

Usage

Description

(3aS,5R,6R,6aS)-6-((tert-butyldiMethylsilyl)oxy)-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde is a complex organic compound that is a derivative of furo[2,3-d][1,3]dioxole. It features a carbonyl group, a tetrahydrofuran ring, and a tert-butyldimethylsilyl group, which contribute to its unique chemical properties and potential applications.

Uses

Used in Organic Synthesis:
(3aS,5R,6R,6aS)-6-((tert-butyldiMethylsilyl)oxy)-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde is used as a protecting group for aldehydes and ketones in organic synthesis. The tert-butyldimethylsilyl group provides stability and can be easily removed when no longer needed, making it a valuable tool in the synthesis of various organic compounds.
Used in Pharmaceutical Synthesis:
(3aS,5R,6R,6aS)-6-((tert-butyldiMethylsilyl)oxy)-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde can also serve as an intermediate in the synthesis of pharmaceuticals. The presence of the tetrahydrofuran ring in its structure may impart unique chemical and biological properties that could be beneficial in the development of new drugs.
Used in Chemical Research:
Due to its structural features, (3aS,5R,6R,6aS)-6-((tert-butyldiMethylsilyl)oxy)-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde may be utilized in chemical research to study the properties of similar compounds, explore new reaction pathways, and understand the reactivity of its functional groups.
Used in the Synthesis of Advanced Materials:
(3aS,5R,6R,6aS)-6-((tert-butyldiMethylsilyl)oxy)-2,2-diMethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde's unique structure may also find applications in the development of advanced materials, such as polymers or other materials with specific properties, where the tetrahydrofuran ring and the carbonyl group could play a crucial role in the material's characteristics.

Upstream product

• 41546-31-0 L-xylose 
• 379269-16-6 5-O-benzoyl-3-O-(tert-butyldimethylsilyl)-1,2-O-isopropylidene-α-L-xylofuranose 
• 131156-47-3 (3aS,3bR,7aS,8aS)-2,2,5,5-tetramethyltetrahydro-3aH-[1,3]dioxolo[4',5':4,5]furo[3,2-d][1,3]dioxane 
• 114861-22-2 1,2-O-isopropylidene-α-L-xylofuranose 
• 166411-39-8 5-O-benzoyl-1,2-O-isopropylidene-7α-L-xylofuranose 
• 609-06-3 L-xylose 
• 379269-17-7 [(3aS,5S,6R,6aS)-6-(tert-butyl-dimethyl-silanyloxy)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-methanol 

Downstream Products

• 379269-19-9 3,5-di-O-benzyl-4-C-[(benzyloxy)methyl]-1,2-O-isopropylidene-β-D-threo-pentofuranose 
• 1416165-32-6 (2S,3S,4R,5S,6S)-2-(4-chloro-3-(4-((trimethylsilyl)ethynyl)benzyl)phenyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1416165-33-7 (2S,3S,4R,5S,6S)-2-(3-(4-acetylbenzyl)-4-chlorophenyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1416164-49-2 1-(4-(2-chloro-5-((2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methoxytetrahydro-2H-pyran-2-yl)benzyl)phenyl)ethanone O-ethyl oxime 
• 1309963-55-0 (3S,4R,5S,6S)-6-(3-(4-acetoxybenzyl)-4-chlorophenyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate 
• 1416165-10-0 (3S,4R,5S,6S)-2-bromo-6-(4-chloro-3-(4-hydroxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1309963-57-2 (2S,3S,4R,5S,6S)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1416165-11-1 (2S,3S,4R,5S,6S)-2-(4-chloro-3-(4-(trifluoromethylsulfonyloxy)benzyl)phenyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1416165-12-2 (2S,3S,4R,5S,6S)-2-(4-chloro-3-(4-cyanobenzyl)phenyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1416165-13-3 4-(2-chloro-5-((2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methoxytetrahydro-2H-pyran-2-yl)benzyl)benzonitrile 
• 1416165-14-4 1-(4-(2-chloro-5-((2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methoxytetrahydro-2H-pyran-2-yl)benzyl)phenyl)ethanone 
• 1416164-41-4 1-(4-(2-chloro-5-((2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methoxytetrahydro-2H-pyran-2-yl)benzyl)phenyl)ethanone O-methyl oxime 
• 1426924-91-5 (2S,3S,4R,5S,6S)-2-(4-chloro-3-(4-(2-(methoxyimino)ethoxy)benzyl)phenyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 1426924-90-4 (2S,35,4R,5S,6S)-2-(4-chloro-3-(4-(2-oxoethoxy)benzyl)phenyl)-6-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate 

Relevant articles and documents

NOVEL SGLT INHIBITORS

The present invention relates to novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula (I), their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula (I) and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).

INHIBITORS OF SODIUM GLUCOSE CO-TRANSPORTER 2 AND METHODS OF THEIR USE

Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity.

Synthesis and antiproliferative activity of some 4′-C-hydroxymethyl α- and -β-D-arabino-pentofuranosyl pyrimidine nucleosides

A suitably protected 4-C-hydroxymethyl-arabino-pentofuranose was prepared and condensed with the following nucleobases: uracil, 5-fluorouracil and thymine. The corresponding cytosine and 5-fluorocytosine derivatives have also been obtained respectively from the uracil and 5-fluorouracil nucleosides. Separation of the anomeric mixtures followed by deprotection afforded the target compounds that were found to be non-cytotoxic to CCRF-CEM leukemia cells.