101909-44-8

Basic information

• Product Name: METHYL 4-IODO-3-INDOLECARBOXYLATE
• Synonyms: METHYL 4-IODO-3-INDOLECARBOXYLATE;4-Iodo-1H-indole-3-carboxylic acid methyl ester;4-Iodo-1H-indole-3-Carbocylic acid methyl ester
• CAS NO: 101909-44-8
• Molecular Formula: C₁₀H₈INO₂
• Molecular Weight: 301.08
• Product Categories: pharmacetical
• Mol File: 101909-44-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 408°Cat760mmHg
• Flash Point: 200.6°C
• Appearance: /
• Density: 1.86g/cm³
• Vapor Pressure: 7.22E-07mmHg at 25°C
• Refractive Index: 1.709
• CAS DataBase Reference: METHYL 4-IODO-3-INDOLECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-IODO-3-INDOLECARBOXYLATE(101909-44-8)
• EPA Substance Registry System: METHYL 4-IODO-3-INDOLECARBOXYLATE(101909-44-8)

Safety Data

• Hazardous Substances Data: 101909-44-8(Hazardous Substances Data)

Usage

General Description

Methyl 4-iodo-3-indolecarboxylate is a chemical compound with the molecular formula C11H8INO2. It is a derivative of indole, a heterocyclic aromatic organic compound. This particular compound is a methyl ester of 4-iodo-3-indolecarboxylic acid, and it is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is often employed as an intermediate in the production of potential anti-cancer drugs and other biologically active molecules. Methyl 4-iodo-3-indolecarboxylate is a highly versatile and valuable compound in the field of organic chemistry due to its potential for creating complex molecules with important biological activities.

InChI:InChI=1/C10H8INO2/c1-14-10(13)6-5-12-8-4-2-3-7(11)9(6)8/h2-5,12H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 106830-34-6 4-iodo-3-indolecarboxylic acid 
• 942-24-5 3-methoxycarbonylindole 
• 72527-73-2 4-iodo-indole-3-carboxaldehyde 

Downstream Products

• 81038-38-2 4-iodo-1H-indole 
• 956469-17-3 (S)-tert-butyl 3-[3-tert-butoxy-2-(diphenylmethyleneamino)-3-oxopropyl]-4-iodo-1H-indole-1-carboxylate 
• 956469-18-4 (S,E)-tert-butyl 3-[3-tert-butoxy-2-(diphenylmethyleneamino)-3-oxopropyl]-4-(3-hydroxy-3-methylbut-1-enyl)-1H-indole-1-carboxylate 
• 33062-26-9 (-)-trans-clavicipitic acid 
• 89434-02-6 4-iodo-3-indoleacetic acid 
• 1149359-60-3 N-(4-chlorophenyl)-4-(pyridin-4-ylmethylthio)-1H-indole-3-carboxamide 
• 1149359-62-5 4-(pyridin-4-ylmethylthio)-N-(3-(trifluoromethyl)phenyl)-1H-indole-3-carboxamide 
• 1149359-65-8 N-(4-t-butylphenyl)-4-(pyridin-4-ylmethylthio)-1H-indole-3-carboxamide 
• 1149359-61-4 N-(3-chlorophenyl)-4-(pyridin-4-ylmethylthio)-1H-indole-3-carboxamide 
• 1149359-63-6 4-(pyridin-4-ylmethylthio)-N-m-tolyl-1H-indole-3-carboxamide 
• 1149359-64-7 N-(3,5-dimethylphenyl)-4-(pyridin-4-ylmethylthio)-1H-indole-3-carboxamide 
• 1149359-71-6 4-(pyridin-4-ylmethylthio)-N-(4-(trifluoromethoxy)phenyl)-1H-indole-3-carboxamide 
• 1296138-70-9 phenyl 1-methyl-4-(1-methyl-1,2,5,6-tetrahydro-4-pyridyl)-3-indolecarboselenoate 
• 1296138-78-7 phenyl 1-methyl-4-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-3-indolecarboselenoate 

Relevant articles and documents

KDR inhibitor with the intramolecular non-bonded interaction: Conformation-activity relationships of novel indole-3-carboxamide derivatives

We previously reported that compound 1, having a similar conformation to PTK787 (2) by forming a pseudo ring structure with an intramolecular non-bonded S-O interaction, exhibited a potent inhibitory activity against VEGFR2 tyrosine kinase (KDR).1/s

A New Synthesis of Lysergic Acid

(Equation presented) (±)-Lysergic acid (1) has been synthesized via an economical 8-step route from 4-bromoindole and isocinchomeronic acid without the need to protect the indole during the synthesis. Initial efforts to form the simpler 3-acylindole derivatives first and then cyclize these were unsuccessful in the cyclization step.

The chemistry of indoles. XXIV. Syntheses of 3-indoleacetic acid and 3-indoleacetonitrile having a halogeno group and a carbon functional group at the 4-position

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