1019338-18-1Relevant articles and documents
Method for preparing chiral amino compound and intermediate thereof
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Paragraph 0089; 0092-0093, (2018/04/03)
The invention discloses a method for preparing a chiral amino compound and intermediate thereof. The method comprises the step of performing a deprotection reaction as shown in the specification on acompound in a formula D and mercaptide in a solvent, wherein in the compound in the formula D, X is selected from O or NMe; Y is Me when X is O, and Y is H when X is NMe; n is selected from 0, 1, 2, 3, 4 or 5; each R is independently NO2 or CN; the mercaptide is salt formed by thiol and metal, and is shown as RS-M; M is an alkali metal ion, and is especially selected from one or more of Li, Na, K, Ru and Cs; and R is C14-24 alkyl. The preparation method is simple and convenient to operate, has mild reaction conditions, high yield and high product quality, and is applicableto industrial production.