1019779-04-4

Basic information

• Product Name: GW791343 (HCl)
• Synonyms: GW791343 (HCl);2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamidetrihydrochloride;GW 791343 hydrochloride;2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]acetamide hydrochloride;GW 791343;GW 791343 dihydrochloride;GW791343 (dihydrochloride);2-((3,4-difluorophenyl)amino)-N-(2-methyl-5-(piperazin-1-ylmethyl)phenyl)acetamide dihydrochloride
• CAS NO: 1019779-04-4
• Molecular Formula: C20H24F2N4O
• Molecular Weight: 374.4275664
• EINECS: 200-258-5
• Product Categories: P2X7 allosteric modulator.
• Mol File: 1019779-04-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Desiccate at RT
• CAS DataBase Reference: GW791343 (HCl)(CAS DataBase Reference)
• NIST Chemistry Reference: GW791343 (HCl)(1019779-04-4)
• EPA Substance Registry System: GW791343 (HCl)(1019779-04-4)

Safety Data

• Hazardous Substances Data: 1019779-04-4(Hazardous Substances Data)

Usage

Description

GW791343 (HCl), also known as GW791343 DTrihydrochloride, is a P2X7 receptor antagonist that functions as an allosteric inhibitor. It exhibits negative allosteric effects at the human P2X7 receptor and positive allosteric effects at the rat P2X7 receptor. The P2X7 receptor plays a crucial role in the presence of inflammatory cells, which are regulated by extracellular ATP.

Uses

Used in Pharmaceutical Industry:
GW791343 (HCl) is used as a P2X7 allosteric modulator for its ability to regulate the P2X7 receptor, which is involved in the presence of inflammatory cells. This modulation can potentially be utilized in the development of treatments for various inflammatory and immune-related conditions.
Used in Research Applications:
GW791343 (HCl) is used as a research tool for studying the role of P2X7 receptors in cellular processes and their potential as therapeutic targets. Its allosteric modulation properties make it a valuable compound for investigating the underlying mechanisms of P2X7 receptor function and its implications in various diseases.
Used in Drug Development:
GW791343 (HCl) is used as a lead compound in the development of new drugs targeting the P2X7 receptor. Its allosteric modulation capabilities can be leveraged to design more effective and selective therapeutic agents for treating conditions related to inflammation, pain, and other P2X7 receptor-mediated processes.

Upstream product

• 309712-80-9 [tert-butoxycarbonyl-(3,4-difluorophenyl)-amino]-acetic acid methyl ester 
• 309712-81-0 [tert-butoxycarbonyl-(3,4-difluorophenyl)-amino]-acetic acid 
• 309712-83-2 4-(3-amino-4-methyl-benzyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 309712-82-1 4-(4-methyl-3-nitro-benzyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 84540-59-0 4-methyl-3-nitrobenzyl chloride 
• 144298-04-4 (3,4-difluorophenyl)-carbamic acid-tert-butyl ester 
• 309712-84-3 4-(3-{2-[-tert-Butoxycarbonyl-(3,4-difluoro-phenyl)-amino]-acetylamino}-4-methyl-benzyl)-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Substituted phenyl compounds with immunosuppressing activity and pharmaceutical compositions

The invention provides substituted phenyl compounds of general formula STR1wherein R 1, T, U and Ar are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.