102005-39-0Relevant articles and documents
One-pot decarboxylative acylation of N-, O-, S-nucleophiles and peptides with 2,2-disubstituted malonic acids
Lebedyeva, Iryna O.,Biswas, Suvendu,Goncalves, Kevin,Sileno, Sean M.,Jackson, Ashton R.,Patel, Kunal,Steel, Peter J.,Katritzky, Alan R.
, p. 11695 - 11698 (2014)
Monocarbonyl activation of 2,2-disubstituted malonic acids with benzotriazole leads to decarboxylation of one of the carboxy groups and formation of a C-H bond. Intermediate carbonyl benzotriazoles then readily acylate nucleophilic reagents and peptides resulting in libraries of conjugates and peptidomimetics.