1020087-07-3

Basic information

• Product Name: (E)-N-[4-(1-{diaminomethylene}hydrazono)ethyl]-4-nitrobenzene hydrochloride
• Synonyms: (E)-N-[4-(1-{diaminomethylene}hydrazono)ethyl]-4-nitrobenzene hydrochloride
• CAS NO: 1020087-07-3
• Molecular Weight: 257.68
• Mol File: 1020087-07-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-N-[4-(1-{diaminomethylene}hydrazono)ethyl]-4-nitrobenzene hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-N-[4-(1-{diaminomethylene}hydrazono)ethyl]-4-nitrobenzene hydrochloride(1020087-07-3)
• EPA Substance Registry System: (E)-N-[4-(1-{diaminomethylene}hydrazono)ethyl]-4-nitrobenzene hydrochloride(1020087-07-3)

Safety Data

• Hazardous Substances Data: 1020087-07-3(Hazardous Substances Data)

Upstream product

• 100-19-6 (4-nitrophenyl)ethanone 

Downstream Products

• 1020087-09-5 (E)-N-[4-(1-{[diaminomethylene]hydrazono}ethyl)phenyl]-4-nitrobenzamide hydrochloride 

Relevant articles and documents

Structure-activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1

A series of 4-anilinoquinoline derivatives related to the known inhibitor SGI-1027, containing side chains of varying pKa, were prepared by acid-catalysed coupling of the pre-formed side chains with 4-chloroquinolines. The compounds were evaluated for their ability to reduce the level of DNMT1 protein in HCT116 human colon carcinoma cells by Western blotting. With a very strongly basic N-methylpyridinium side chain, only NHCO-linked compounds were effective, whereas less strongly basic ((diaminomethylene)hydrazono)ethyl or 3-methylpyrimidine-2,4-diamine side chains allowed both NHCO- and CONH-linked compounds to show activity. In contrast, the pKa of the quinoline unit had little apparent influence on activity.