102028-50-2Relevant articles and documents
Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity
Manfredini, Stefano,Pavan, Barbara,Vertuani, Silvia,Scaglianti, Martina,Compagnone, Donatello,Biondi, Carla,Scatturin, Angelo,Tanganelli, Sergio,Ferraro, Luca,Prasad, Puttur,Dalpiaz, Alessandro
, p. 559 - 562 (2002)
To improve the entry of certain drugs into brain, ascorbic acid (AA) conjugates of these drugs were synthesized and their capacity to interact with SVCT2 ascorbate transporters was explored. Kinetic studies clearly indicate that all of the conjugates were
Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules
Manfredini, Stefano,Vertuani, Silvia,Pavan, Barbara,Vitali, Federica,Scaglianti, Martina,Bortolotti, Fabrizio,Biondi, Carla,Scatturin, Angelo,Prasad, Puttur,Dalpiaz, Alessandro
, p. 5453 - 5463 (2007/10/03)
Preliminary investigations allowed us to anticipate that conjugation of nipecotic acid with l-ascorbate (AA) gave a prodrug endowed with anticonvulsant activity in mice. In view of these results, and in order to get deepen insight into the molecular aspec
