102061-02-9

Basic information

• Product Name: (S)-2-hydroxymethyl-N-((R)-2-hydroxy-2-phenyl)-acetyl pyrrolidine
• Synonyms: (S)-2-hydroxymethyl-N-((R)-2-hydroxy-2-phenyl)-acetyl pyrrolidine
• CAS NO: 102061-02-9
• Molecular Weight: 235.283
• Mol File: 102061-02-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (S)-2-hydroxymethyl-N-((R)-2-hydroxy-2-phenyl)-acetyl pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-hydroxymethyl-N-((R)-2-hydroxy-2-phenyl)-acetyl pyrrolidine(102061-02-9)
• EPA Substance Registry System: (S)-2-hydroxymethyl-N-((R)-2-hydroxy-2-phenyl)-acetyl pyrrolidine(102061-02-9)

Safety Data

• Hazardous Substances Data: 102061-02-9(Hazardous Substances Data)

Upstream product

• 36825-11-3 2-isobutylidene malonic acid dimethyl ester 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 219598-57-9 (S)-2-hydroxymethyl-N,O-bisbenzoylformyl pyrrolidine 
• 219598-58-0 (S)-2-hydroxymethyl-N-benzoylformyl pyrrolidine 
• 100-58-3 phenylmagnesium bromide 
• 214834-74-9 (3S,8aS)-3-Hydroxy-tetrahydro-pyrrolo[2,1-c][1,4]oxazin-4-one 
• 102061-00-7 N-phenylacetyl-L-proplinol 

Downstream Products

• 611-71-2 (R)-Mandelic Acid 
• 20698-91-3 (R)-methyl mandelate 
• 17199-29-0 (S)-Mandelic acid 

Relevant articles and documents

Synthesis and utilisation of chiral 3-hydroxy perhydropyrrolo [2,1-c] [1,4] oxazin-4-one as a novel precursor for the enantioselective synthesis of α-hydroxy carboxylic acids

A novel strategy for the enantioselective synthesis of several α- hydroxy carboxylic acids by the nucleophilic alkylation of chiral 3-hydroxy- (3S, 8aS)-perhydropyrrolo [2,1-C] [1,4] oxazin -4 one is reported.

Photoinduced electron transfer (PET) promoted oxidative activation of 1- (N-benzyl-N-methylglycyl)-(S)-prolinol: Development of novel strategies towards enantioselective syntheses of α-amino acids, their N-methyl derivatives and α-hydroxy acids employing

PET activation of 1-(N-benzyl-N-methylglycyl)-(S)-prolinol (1) in dry acetonitrile, utilizing 1,4-dicyanonaphthalene (DCN) as a light-harvesting electron-acceptor and methyl viologen (MV++) as an electron-transfer mediator, leads to the formati

Asymmetric reactions of α-ketoacid-derived hemiacetals: Stereoselective synthesis of α-hydroxy acids

N-Acylation of prolinol with α-ketoacid chlorides results in concomitant hemiacetalization of the α-keto amide by the prolinol hydroxyl group. (R) or (S) α-hydroxy acids are obtained with good enantiomeric excess by stereodivergent reduction of these hemiacetals. Reaction with Grignard reagents at ambient temperature furnishes (R) α-alkyl mandelic acids with good stereoselectivity.