1020727-14-3Relevant articles and documents
Rapid identification of the pharmacophore in a peptoid inhibitor of the proteasome regulatory particle
Lim, Hyun-Suk,Archer, Chase T.,Kim, Young-Chan,Hutchens, Troy,Kodadek, Thomas
, p. 1064 - 1066 (2008/12/22)
Here we report a simple and effective method to identify the minimal pharmacophore in the first peptoid inhibitor of the 19S proteasome regulatory particle, which has led to the development of a derivative that exhibits improved cellular activity, presumably due to a reduction in mass of about two-fold and the elimination of positively charged lysine-like residues. The Royal Society of Chemistry.