102130-85-8

Basic information

• Product Name: 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, phenylmethyl ester, (S)-
• CAS NO: 102130-85-8
• Molecular Formula: C19H18N2O2
• Molecular Weight: 306.364
• Mol File: 102130-85-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, phenylmethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, phenylmethyl ester, (S)-(102130-85-8)
• EPA Substance Registry System: 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, phenylmethyl ester, (S)-(102130-85-8)

Safety Data

• Hazardous Substances Data: 102130-85-8(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 22839-16-3 L-tryptophan benzyl ester hydrochloride 
• 22839-16-3 L-tryptophan benzyl ester hydrochloride 
• 42438-90-4 3-carboxy-1,2,3,4-tetrahydro-2-carboline 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 73-22-3 L-Tryptophan 
• 66863-43-2 (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid 

Relevant articles and documents

Indole-TEMPO conjugates alleviate ischemia-reperfusion injury via attenuation of oxidative stress and preservation of mitochondrial function

Mitochondrial oxidative damage contributes to a wide range of pathologies including ischemia/reperfusion injury. Accordingly, protecting mitochondria from oxidative damage should possess therapeutic relevance. In the present study, we have designed and synthesized a series of novel indole-TEMPO conjugates that manifested good anti-inflammatory properties in a murine model of xylene-induced ear edema. We have demonstrated that these compounds can protect cells from simulated ischemia/reperfusion (s-I/R)-induced reactive oxygen species (ROS) overproduction and mitochondrial dysfunction. Furthermore, we have demonstrated that indole-TEMPO conjugates can attenuate organ damage induced in rodents via intestinal I/R injury. We therefore propose that the pharmacological profile and mechanism of action of these indole-TEMPO conjugates involve convergent roles, including the ability to decrease free radical production via lipid peroxidation which couples to an associated decrease in ROS-mediated activation of the inflammatory process. We further hypothesize that the protective effects of indole-TEMPO conjugates partially reside in maintaining optimal mitochondrial function.

Side chain protected aminoamido n-hexanoyl carboline carboxylic acid benzyl ester, preparation, activity and applications thereof

The invention discloses (3S)-N-(6-aminoamido-n-hexanoyl)-2,3,4,9-tetrahydro-beta-carboline-3-carboxylic acid benzyl ester having the following structure (AA in the formula is selected from L-Asp (OBzl) residue, L-Glu (OBzl) residue and L-Arg (NO2) residue), a preparation method and antitumor applications thereof, and further relates to applications in preparation of antitumor drugs.

Benzyl glutamine aminohexyl carboline carboxylate, and preparation, activity and application thereof

The invention discloses benzyl (3S)-N-(6-Gln-amino-n-hexyl)-2,3,4,9-tetrahydro-beta-carbolin-3-carboxylate having the following structure described in the specification, and a preparation method and lung cancer metastasis resistance dose-dependent relationship thereof, an anti-inflammatory effect thereof, and an application thereof in preparation of anti-tumor metastasis drugs and anti-inflammatory drugs.