1021363-43-8

Basic information

• Product Name: 4-(4-Cyano-benzyl)-piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(4-Cyano-benzyl)-piperidine-1-carboxylic acid tert-butyl ester;tert-Butyl 4-(4-cyanobenzyl)piperidine-1-carboxylate
• CAS NO: 1021363-43-8
• Molecular Formula: C₁₈H₂₄N₂O₂
• Molecular Weight: 300.39536
• Mol File: 1021363-43-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4-Cyano-benzyl)-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Cyano-benzyl)-piperidine-1-carboxylic acid tert-butyl ester(1021363-43-8)
• EPA Substance Registry System: 4-(4-Cyano-benzyl)-piperidine-1-carboxylic acid tert-butyl ester(1021363-43-8)

Safety Data

• Hazardous Substances Data: 1021363-43-8(Hazardous Substances Data)

Usage

General Description

4-(4-Cyano-benzyl)-piperidine-1-carboxylic acid tert-butyl ester is a chemical compound with a complex molecular structure. It is a piperidine derivative with a cyano-benzyl functional group and a tert-butyl ester group attached to the carboxylic acid moiety. The compound is typically used as a building block or precursor in organic synthesis, particularly in the pharmaceutical industry for the development of new drugs. It may also have some potential biological activity, although further research is needed to fully understand its properties and potential applications. Overall, this compound is of interest to chemists and researchers for its unique structure and potential utility in chemical and pharmaceutical synthesis.

Upstream product

• 333987-57-8 4-(piperidin-4-ylmethyl)benzonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 17201-43-3 4-cyanobenzyl bromide 
• 1552-41-6 diethyl [(4-cyanophenyl)methyl]phosphonate 
• 888729-74-6 tert-butyl 4-(4-cyanobenzylidene)piperidine-1-carboxylate 

Relevant articles and documents

NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS

The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses as drugs, especially for treatment and prevention of tissue fibrosis. Also provided herein are pharmaceutically acceptable compositions comprising the nitrogenous heterocyclic compounds and the uses of the compositions in the treatment of human or animal tissue fibrosis, especially for human or animal renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, IPF, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, postsurgical adhesion, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, alzheimer disease or vascular fibrosis.

Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent anti-HIV-1 activity

We incorporated various polar groups into previously described piperidine-4-carboxamide CCR5 antagonists to improve their metabolic stability in human hepatic microsomes. Introducing a carbamoyl group into the phenyl ring of the 4-benzylpiperidine moiety