102146-49-6

Basic information

• Product Name: Benzaldehyde, 2,4-dichloro-, hydrazone
• CAS NO: 102146-49-6
• Molecular Formula: C7H6Cl2N2
• Molecular Weight: 189.044
• Mol File: 102146-49-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 2,4-dichloro-, hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 2,4-dichloro-, hydrazone(102146-49-6)
• EPA Substance Registry System: Benzaldehyde, 2,4-dichloro-, hydrazone(102146-49-6)

Safety Data

• Hazardous Substances Data: 102146-49-6(Hazardous Substances Data)

Upstream product

• 108-88-3 toluene 
• 95-73-8 2,4-dichlorotoluene 
• 1006570-57-5 2-(2,4-dichloro-benzylidene)amino-benzo[de]isoquinolin-1,3-dione 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 5051-49-0 2,4-dichlorobenzaldehyde, dimethylhydrazone 

Downstream Products

• 40092-36-2 C₁₁H₁₃Cl₂N₃O 
• 6319-33-1 1,2-bis(2,4-dichlorobenzylidene)hydrazine 
• 842141-94-0 1-(3-bromo-2,2,3,3-tetrafluoropropyl)-2,4-dichlorobenzene 
• 304481-70-7 N'-(2,4-dichlorobenzylidene)-3,4-dihydroxybenzohydrazide 
• 1226600-25-4 C₉H₄Cl₂F₄ 

Relevant articles and documents

One-Pot Synthesis of 3-(2-Fluoroalkenyl)indoles

An unprecedented one-pot synthesis of 3-(fluoroalkenyl)indoles was developed. This process involves a catalyst-free Michael addition of β-fluoro-β-nitrostyrenes to indoles in neat followed by elimination of HNO2 using DBU as a base. The effectiveness of this approach was demonstrated through the preparation of variety of target products in up to 75 % isolated yield.

Synthesis, in-vitro and in-silico studies of triazinoindole bearing bis-Schiff base as β-glucuronidase inhibitors

Triazinoindole bearing bis-Schiff base analogs (1–20) were synthesized by triazinoindole-thione ring formation, triazinoindole-thiol-phenylethanone, followed by triazinoindole bis-Schiff base formation. Synthesized analogs showed β-glucuronidase potential with IC50 value ranging between 2.60 ± 0.10 to 55.40 ± 1.60 μM as compared to standard D-saccharic acid 1,4-lactone (IC50 = 48.10 ± 1.2 μM). Analog 20 was the most potent one with IC50 value 2.60 ± 0.10 μM. Analogs 17, 4 showed IC50 values 5.20 ± 0.20 and 5.70 ± 0.20 μM respectively and withstand 2nd and 3rd ranked scaffolds among the synthesized analogs. All other sixteen analogs showed many-fold better potency with IC50 values ranging from 7.9 ± 0.2 to 48.1 ± 1.2 μM. The structure-activity relationship was established and confirmed of binding interactions through molecular docking studies.

Ionic liquids as a reusable media for copper catalysis. Green access to alkenes using catalytic olefination reaction

It was demonstrated that ionic liquids are superb recyclable media for copper catalyzed reactions using catalytic olefination reaction as an example. As a result a novel green access to the halogenoalkenes was elaborated. Possibility to perform up to five reaction cycles without catalyst leaching and decreasing of the yield was demonstrated. A number of various ionic liquids was screened and 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim] [BF4]) was found the solvent with highest efficiency. Mild conditions, high atom economy comparing to other known methods, low amounts of wastes and possibility to recover ionic liquid are the advantages of the proposed method.