1021948-09-3Relevant articles and documents
Chemo-enzymatic dynamic kinetic resolution of amino acid thioesters
Arosio, Dario,Caligiuri, Antonio,D'Arrigo, Paola,Pedrocchi-Fantoni, Giuseppe,Rossi, Cristina,Saraceno, Caterina,Servi, Stefano,Tessaro, Davide
, p. 1345 - 1348 (2007)
The L-forms of racemic-N-protected-β,γa,aunsaturated a-amino acid thioesters were found to be substrates for the subtilisin-catalysed hydrolysis to the corresponding acids. The D-enantiomer was continuously racemised in the presence of an organic base. The combined reactions in a biphasic system allowed the deracemisation of the amino acid derivatives based on a dynamic kinetic resolution. Excellent yields and enantioselectivities were achieved.
