102269-42-1

Basic information

• Product Name: 3-(2-FURYL)ANILINE
• Synonyms: AKOS B025039;AKOS BAR-0083;3-FURAN-2-YL-PHENYLAMINE;3-(2-FURYL)ANILINE;CHEMBRDG-BB 4003071;ART-CHEM-BB B025039;3-(2-Furyl)aniline 97%;[3-(2-furyl)phenyl]amine hydrochloride
• CAS NO: 102269-42-1
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18
• Mol File: 102269-42-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 53 °C
• Boiling Point: 312.3 °C at 760 mmHg
• Flash Point: 142.7 °C
• Appearance: /
• Density: 1.138 g/cm³
• Vapor Pressure: 0.000533mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 3-(2-FURYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-FURYL)ANILINE(102269-42-1)
• EPA Substance Registry System: 3-(2-FURYL)ANILINE(102269-42-1)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 102269-42-1(Hazardous Substances Data)

Usage

General Description

3-(2-Furyl)aniline is a chemical compound with the molecular formula C10H10N2O, consisting of a benzene ring with a furan ring and an amine group. It is commonly used in the manufacture of dyes, pharmaceuticals, and other organic compounds. The compound has been found to exhibit antimicrobial, anti-inflammatory, and anticancer properties, making it a potential candidate for various medical and pharmaceutical applications. It is important to handle 3-(2-Furyl)aniline with caution due to its toxic and hazardous nature.

InChI:InChI=1/C10H9NO/c11-9-4-1-3-8(7-9)10-5-2-6-12-10/h1-7H,11H2

Upstream product

• 28988-01-4 2-(3-nitrophenyl)-furan 
• 585-79-5 m-nitrobromobenzene 
• 13331-23-2 fur-2-ylboronic acid 
• 591-19-5 m-Bromoaniline 
• 30418-59-8 3-Aminophenylboronic acid 
• 408492-37-5 2-(n-butyltellanyl)furan 

Downstream Products

• 102269-44-3 2-[(3-Furan-2-yl-phenylamino)-methylene]-malonic acid diethyl ester 
• 102269-47-6 Diethyl 7-(furyl-2)-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 1443438-22-9 C₂₅H₂₀F₆N₂O₃ 
• 1028338-76-2 1,4-dichloro-phthalazine-6-carboxylic acid (3-furan-2-yl-phenyl)-amid 

Relevant articles and documents

Discovery, optimization and evaluation of 1-(indolin-1-yl)ethan-1-ones as novel selective TRIM24/BRPF1 bromodomain inhibitors

TRIM24 (tripartite motif-containing protein 24) and BRPF1 (bromodomain and PHD finger containing protein 1) are epigenetics “readers” and potential therapeutic targets for cancer and other diseases. Here we describe the structure-guided design of 1-(indolin-1-yl)ethan-1-ones as novel TRIM24/BRPF1 bromodomain inhibitors. The representative compound 20l (Y08624) is a new TRIM24/BRPF1 dual inhibitor, with IC50 values of 0.98 and 1.16 μM, respectively. Cellular activity of 20l was validated by viability assay in prostate cancer (PC) cell lines. In PC xenograft models, 20l suppressed tumor growth (50 mg/kg/day, TGI = 53%) without exhibiting noticeable toxicity. Compound 20l represents a versatile starting point for the development of more potent TRIM24/BRPF1 inhibitors.

Synthesis of 2-aryl- and 2,5-diarylfurans and thiophenes by Suzuki-Miyaura reactions using potassium trifluoroborate salts and heteroaryltellurides

The Suzuki-Miyaura cross-coupling reaction of 2-(butyltellanyl) or 2,5-bis-(butyltellanyl)furans and thiophenes with potassium aryltrifluoroborate salts catalyzed by palladium afforded 2-aryl- or 2,5-diaryl-furans and thiophenes in moderate to good yields.