1022931-73-2Relevant articles and documents
A novel series of positive modulators of the AMPA receptor: Structure-based lead optimization
Jamieson, Craig,Campbell, Robert A.,Cumming, Iain A.,Gillen, Kevin J.,Gillespie, Jonathan,Kazemier, Bert,Kiczun, Michael,Lamont, Yvonne,Lyons, Amanda J.,MacLean, John K.F.,Martin, Frederic,Moir, Elizabeth M.,Morrow, John A.,Pantling, John,Rankovic, Zoran,Smith, Lynn
, p. 6072 - 6075 (2010)
Starting from lead compound 1, we demonstrate how X-ray structural data can be used to understand SAR and expediently optimize bioavailability in a novel series of AMPA receptor modulators, furnishing 5 with improved bioavailability and robust in vivo activity.