1022960-45-7

Basic information

• Product Name: 2-aMino-3-broMo-N-Methyl-benzaMide
• Synonyms: 2-aMino-3-broMo-N-Methyl-benzaMide
• CAS NO: 1022960-45-7
• Molecular Formula: C₈H₉BrN₂O
• Molecular Weight: 229.07386
• Mol File: 1022960-45-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-aMino-3-broMo-N-Methyl-benzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aMino-3-broMo-N-Methyl-benzaMide(1022960-45-7)
• EPA Substance Registry System: 2-aMino-3-broMo-N-Methyl-benzaMide(1022960-45-7)

Safety Data

• Hazardous Substances Data: 1022960-45-7(Hazardous Substances Data)

Usage

Class

amines and amides
Derivative of N-methylbenzamide
Contains amino group at 2 position
Contains bromine atom at 3 position on benzene ring
Used as building block in organic synthesis and medicinal chemistry
Potential intermediate in production of pharmaceuticals and agrochemicals
Suitable for various research and industrial applications

Upstream product

• 91-56-5 indole-2,3-dione 
• 20776-51-6 2-amino-3-bromo benzoic acid 
• 74-89-5 methylamine 
• 20780-74-9 7-bromoisatin 

Downstream Products

• 1410974-28-5 3-bromo-2-(2-methoxyacetamido)-N-methylbenzamide 
• 1341038-12-7 8-bromo-3-methyl-3H-quinazolin-4-one 

Relevant articles and documents

Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors

The high expression of proviral insertion site of Moloney murine leukemia virus kinases (Pim-1, -2, and -3) in cancers, particularly the hematopoietic malignancies, is believed to play a role in promoting cell survival and proliferation while suppressing apoptosis. The three isoforms of Pim protein appear largely redundant in their oncogenic functions. Thus, a pan-Pim kinase inhibitor is highly desirable. However, cell active pan-Pim inhibitors have proven difficult to develop because Pim-2 has a low Km for ATP and therefore requires a very potent inhibitor to effectively block the kinase activity at cellular ATP concentrations. Herein, we report a series of quinazolinone-pyrrolopyrrolones as potent and selective pan-Pim inhibitors. In particular, compound 17 is orally efficacious in a mouse xenograft model (KMS-12 BM) of multiple myeloma, with 93% tumor growth inhibition at 50 mg/kg QD upon oral dosing.

Bicyclic heteroaryl compound with PAR4 antagonistic activity and application thereof

The invention discloses a bicyclic heteroaryl compound with PAR4 antagonistic activity and application thereof. The invention provides the bicyclic heteroaryl compound with PAR4 antagonistic activity,and the bicyclic heteroaryl compound has remarkable antagonistic activity on PAR4 in an in-vitro anti-platelet aggregation experiment, so that platelet aggregation is effectively inhibited, and the bicyclic heteroaryl compound can be used for preparing medicines for preventing or treating various thromboembolic diseases.