10234-66-9Relevant articles and documents
Method for producing 1 substituted 5-chloro-4 methly pyrazoles
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, (2008/06/13)
The present invention relates to a process for preparing 1-substituted 5-chloro-4-methylpyrazoles of the general formula I with the meaning for R stated in claim 1, in which a 4-methylpyrazole of the formula II is reacted with chlorine, the resulting mixture of monochlorinated and dichlorinated product is fractionated by distillation, and subsequently the dichlorinated compound is dehalogenated to compound II and returned to the reaction with chlorine.
Selective N-methylation of pyrazolone with methanol by use of ZrO2 catalyst in the liquid phase
Shinoda, Sumio,Shima, Satoru,Yamakawa, Tetsu
, p. 809 - 810 (2007/10/03)
Selective methylation of pyrazolone to 1-methylpyrazolone was investigated with ZrO2, which is a representative metal oxide with amphoteric character. The high selectivity up to ~7% was obtained at 503 K. Mechanism is proposed in view of weak acidic-moderately basic pair sites of ZrO2.
REGIOSELECTIVE NUCLEOPHILIC SUBSTITUTION IN ACTIVATED 1-AMINOPYRAZOLIUM CATIONS: A FACILE SYNTHESIS OF 5-SUBSTITUTED 1-METHYLPYRAZOLES
Bruix, Marta,Castellanos, M. Luisa,Martin, M. Rosario,Mendoza, Javier de
, p. 5485 - 5488 (2007/10/02)
5-Substituted 1-methylpyrazoles were easily obtained in good yields by the attack of nucleophiles (NaCN, H2O, EtSH, pyrazole, imidazole) to 2,6-dimethyl-1-(2-methylpyrazol-1-io)-4-phenylpyridinium bistetrafluoroborate (1b), without significant formation o