1024656-05-0

Basic information

• Product Name: 1-benzyl-4-(4-chlorophenyl)-5-phenyl-1H-[1,2,3]triazole
• Synonyms: 1-benzyl-4-(4-chlorophenyl)-5-phenyl-1H-[1,2,3]triazole
• CAS NO: 1024656-05-0
• Molecular Weight: 345.831
• Mol File: 1024656-05-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-benzyl-4-(4-chlorophenyl)-5-phenyl-1H-[1,2,3]triazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-(4-chlorophenyl)-5-phenyl-1H-[1,2,3]triazole(1024656-05-0)
• EPA Substance Registry System: 1-benzyl-4-(4-chlorophenyl)-5-phenyl-1H-[1,2,3]triazole(1024656-05-0)

Safety Data

• Hazardous Substances Data: 1024656-05-0(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 1009089-47-7 1‐benzyl‐4‐(4‐chlorophenyl)‐1H‐1,2,3‐triazole 
• 591-50-4 iodobenzene 
• 100-39-0 benzyl bromide 
• 120106-67-4 4-(4-chlorophenyl)-5-phenyl-1H(2H)-[1,2,3]triazole 
• 1130489-31-4 C₁₅H₁₂IN₃ 
• 195062-61-4 4-chlorophenylboronic acid pinacol ester 
• 873-73-4 4-n-chlorophenylacetylene 
• 622-79-7 benzyl azide 
• 98-80-6 phenylboronic acid 
• 3240-10-6 (4-chlorophenyl)propiolic acid 

Relevant articles and documents

Copper-catalyzed: In situ oxidative-coupling for one-pot synthesis of 5-aryl-1,4-disubstituted 1,2,3-triazoles under mild conditions

A new reaction system with CuCl as catalyst, TEA as base and O2/chloramine-T as oxidant was developed for one-pot in situ oxidative-coupling to synthesize 5-aryl-1,4-disubstituted 1,2,3-triazoles in this paper. A variety of 5-arylated-1,2,3-triazole compounds could be efficiently prepared directly from the readily accessible organic azides, terminal alkynes and arylboronic acids. Advantages of the method include use of low-cost catalyst, clean oxidant, less-toxic additive, and low reaction temperature. Importantly, due to avoiding harsh strong basic reagents and high temperatures, the presented method can offer mild conditions for multi-component synthesis of 5-aryl-1,2,3-triazoles from the designed structurally complicated alkynyl or azide donors bearing natural product motifs and sensitive functional groups.

Pd-catalyzed ligand-free C(5)–H arylation of 1,4-disubstituted 1,2,3-triazoles promoted by microwaves

Pd(OAc)2-catalyzed regioselective C(5)–H arylation of 1,4-disubstituted 1,2,3-triazoles was achieved without ligand under microwave conditions in 1 h, generating 1,4,5-trisubstituted 1,2,3-triazoles with good to excellent yields. The obtained molecules can be easily converted into 4,5-disubstituted 1,2,3-triazoles through the debenzylation process with one-pot manipulation.

N-substituted-1,2,3-triazoles: Synthesis, characterization and evaluation as cannabinoid ligands

A series of new N1-, N2-and N3-substituted 1,2,3-triazole derivatives has been synthesized by cycloaddition of butyltin azide with substituted alkynes followed by a N-alkylation reaction. The regioisomers have been isolated and characterized using NMR tec