1025687-58-4 Usage
Description
R788 (Fostamatinib disodium) is a sodium salt derivative of R788, which functions as a selective spleen tyrosine kinase (Syk) inhibitor. R788(Fostamatinib disodium) plays a significant role in modulating immune responses and has demonstrated potential in treating various medical conditions.
Uses
Used in Pharmaceutical Industry:
R788 (Fostamatinib disodium) is used as a therapeutic agent for the treatment of autoimmune diseases such as type 1 diabetes. Its Syk-inhibiting properties help in regulating the immune system and provide relief from the symptoms associated with these conditions.
Additionally, R788 (Fostamatinib disodium) is used as a treatment option for patients with rheumatoid arthritis. By inhibiting Syk, it helps in reducing inflammation and alleviating the pain and stiffness associated with the disease.
In the field of oncology, R788 (Fostamatinib disodium) is used as a targeted therapy for the treatment of leukemia and lymphoma. Its ability to inhibit Syk makes it a promising candidate for cancer treatment, as it can potentially disrupt the signaling pathways that promote cancer cell growth and survival.
Furthermore, R788 (Fostamatinib disodium) has been tested in clinical trials for its potential use in treating other immune-mediated conditions, highlighting its versatility and wide-ranging applications in the medical field.
Biological Activity
r788, which is the prodrug of r406, is a potnet and selective syk inhibitor. the spleen tyrosine kinase (syk) plays a key role in the signaling of activating fc receptors and the b-cell receptor (bcr).
in vitro
r406 was found to induce the apoptosis of the majority of examined dlbcl cell lines and could specifically inhibit both tonic- and ligand-induced bcr signaling (autophosphorylation of syk525/526 and sykdependent phosphorylation of the b-cell linker protein [blnk]) [1].
in vivo
r788 effectively inhibits bcr signaling, demonstrating reduced proliferation and survival of the malignant b cells and significantly prolonged survival of the treated eμ-tcl1 transgenic mouse. moreover, the effect of r788 was found to be selective for the malignant clones, since no disturbance in the production of normal b lymphocytes was observed [2].
references
[1] chen l, monti s, juszczynski p, daley j, chen w, witzig te, habermann tm, kutok jl, shipp ma. syk-dependent tonic b-cell receptor signaling is a rational treatment target in diffuse large b-cell lymphoma. blood. 2008 feb 15;111(4):2230-7. [2] suljagic m, longo pg, bennardo s, perlas e, leone g, laurenti l, efremov dg. the syk inhibitor fostamatinib disodium (r788) inhibits tumor growth in the eμ- tcl1 transgenic mouse model of cll by blocking antigen-dependent b-cell receptor signaling. blood. 2010 dec 2;116(23):4894-905.[3] bajpai m. fostamatinib, a syk inhibitor prodrug for the treatment of inflammatory diseases. idrugs. 2009 mar;12(3):174-85.
Check Digit Verification of cas no
The CAS Registry Mumber 1025687-58-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,2,5,6,8 and 7 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1025687-58:
(9*1)+(8*0)+(7*2)+(6*5)+(5*6)+(4*8)+(3*7)+(2*5)+(1*8)=154
154 % 10 = 4
So 1025687-58-4 is a valid CAS Registry Number.
