1025938-75-3Relevant articles and documents
Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: Synthesis and biological activities of a series of 1- pyridylnaphthalene derivatives
Ukita, Tatsuzo,Sugahara, Masakatsu,Terakawa, Yoshihiro,Kuroda, Tooru,Wada, Kazuteru,Nakata, Aya,Ohmachi, Yasushi,Kikkawa, Hideo,Ikezawa, Katsuo,Naito, Kazuaki
, p. 1088 - 1099 (2007/10/03)
The structural requirements for potent and selective PDE4 inhibition were revealed in a 1-pyridylnaphthalene series, and the best compound (3kg, T-2585·HCl) was chosen for further biological evaluation (PDE4 inhibition IC50 = 0.13 nM, selectivi