1026-89-7 Usage
Description
(-)-Sotalol hydrochloride, also known as S(-)-Sotalol, is a medication used to treat certain types of irregular heartbeats, specifically ventricular arrhythmias. It belongs to a class of drugs known as beta-blockers and works by slowing down the heart rate and reducing the force of contractions, which helps to restore a regular heartbeat. The chemical compound is a racemic mixture consisting of both R(+) and S(-) enantiomers, with the S(-)-Sotalol enantiomer being the active form.
Uses
Used in Cardiology:
(-)-Sotalol hydrochloride is used as an antiarrhythmic agent for the treatment of ventricular arrhythmias. It helps to regulate the heart rate and reduce the force of contractions, which aids in restoring a regular heartbeat.
Used in Pharmaceutical Industry:
(-)-Sotalol hydrochloride is used as an active pharmaceutical ingredient in the formulation of oral tablets. It has a long duration of action, requiring careful monitoring and dosing adjustments to prevent potential side effects such as life-threatening arrhythmias, dizziness, and low blood pressure.
Used in Drug Interaction Management:
(-)-Sotalol hydrochloride is used as a medication that requires careful consideration of potential drug interactions. It may interact with other drugs and should not be used in certain individuals with specific heart conditions or electrolyte imbalances.
Check Digit Verification of cas no
The CAS Registry Mumber 1026-89-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,2 and 6 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1026-89:
(6*1)+(5*0)+(4*2)+(3*6)+(2*8)+(1*9)=57
57 % 10 = 7
So 1026-89-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
1026-89-7Relevant articles and documents
A short synthesis of d-sotalol
Smith,Brodfuehrer,Dillon,Vemishetti
, p. 1093 - 1098 (1995)
Asymmetric synthesis of d-sotalol (2) was accomplished by chiral homogenous hydrogenation of (4-isopropylaminoacetyl)methanesulfonanilide hydrochloride (1).
Synthesis of (S)-(+)-sotalol and (R)-(-)-isoproterenol via a catalytic enantioselective Henry reaction
Blay, Gonzalo,Hernandez-Olmos, Victor,Pedro, Jose R.
experimental part, p. 578 - 581 (2010/08/06)
A unified approach for the synthesis of (S)-(+)-sotalol and (R)-(-)-isoproterenol has been developed. The enantioselective Henry reaction of the appropriate aldehyde in the presence of a camphor-derived amino pyridine-Cu(II) complex was the key step of th
