1026009-77-7

Basic information

• Product Name: 1-(3-dimethylamino-propyl)-1-phenyl-1,3-dihydro-isobenzofuran-5-carbonitrile
• Synonyms: 1-(3-dimethylamino-propyl)-1-phenyl-1,3-dihydro-isobenzofuran-5-carbonitrile
• CAS NO: 1026009-77-7
• Molecular Weight: 306.407
• Mol File: 1026009-77-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(3-dimethylamino-propyl)-1-phenyl-1,3-dihydro-isobenzofuran-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-dimethylamino-propyl)-1-phenyl-1,3-dihydro-isobenzofuran-5-carbonitrile(1026009-77-7)
• EPA Substance Registry System: 1-(3-dimethylamino-propyl)-1-phenyl-1,3-dihydro-isobenzofuran-5-carbonitrile(1026009-77-7)

Safety Data

• Hazardous Substances Data: 1026009-77-7(Hazardous Substances Data)

Upstream product

• 773837-37-9 sodium cyanide 
• 1026263-04-6 {3-[5-bromo-1-phenyl-1,3-dihydro-isobenzofuran-1-yl]-propyl}-dimethyl-amine 

Downstream Products

• 1029696-33-0 1-(3-methylamino-propyl)-1-phenyl-1,3-dihydro-isobenzofuran-5-carbonitrile 
• 1093072-86-6 1-(3-dimethylamino-propyl)-1-phenyl-1,3-dihydro-isobenzofuran-5-carbonitrile oxalate 

Relevant articles and documents

NOVEL 1,3-DIHYDRO-5-ISOBENZOFURANCARBONITRILE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR THE TREATMENT OF PREMATURE EJACULATION

Disclosed herein are novel 1,3-dihydro-5-isobenzofurancarbonitrile derivatives represented by Formula 1, or pharmaceutically acceptable salts thereof. Also disclosed is a pharmaceutical composition for treating or preventing premature ejaculation including the compound. The 1,3-dihydro-5-isobenzofurancarbonitrile derivatives have a short half-life and inhibit the ejaculation process by selectively inhibiting serotonin reuptake via a serotonin reuptake transporter present in a presynaptic neuron. Thus, the compounds are useful in the treatment and prevention of premature ejaculation.

From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: Synthesis and structure-activity relationship studies

Citalopram and talopram are structurally closely related, but they have very distinct pharmacological profiles as selective inhibitors of the serotonin and norepinephrine transporters, respectively. A systematic structure-activity relationship study was p