1026222-44-5

Basic information

• Product Name: 3,4,5,6-tetrafluoro-N-(3-methyl-2-oxo-piperidin-3-yl)-phthalamic acid
• CAS NO: 1026222-44-5
• Molecular Weight: 348.254
• Mol File: 1026222-44-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,4,5,6-tetrafluoro-N-(3-methyl-2-oxo-piperidin-3-yl)-phthalamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5,6-tetrafluoro-N-(3-methyl-2-oxo-piperidin-3-yl)-phthalamic acid(1026222-44-5)
• EPA Substance Registry System: 3,4,5,6-tetrafluoro-N-(3-methyl-2-oxo-piperidin-3-yl)-phthalamic acid(1026222-44-5)

Safety Data

• Hazardous Substances Data: 1026222-44-5(Hazardous Substances Data)

Upstream product

• 652-12-0 4,5,6,7-tetrafluoroisobenzofuran-1,3-dione 
• 123979-16-8 (S)-3-amino-3-methylpiperidine-2-one 

Relevant articles and documents

Tumor necrosis factor-alpha production enhancing activity of substituted 3'-methylthalidomide: Influence of substituents at the phthaloyl moiety on the activity and stereoselectivity

The synthesis and tumor necrosis factor (TNF)-α production enhancing activity of substituted 3'-methyl-thalidomides on human leukemia cell line HL-60 stimulated with 12-O-tetradecanoyl-phorbol 13-acetate (TPA) are described. Though the introduction of an electron-donating amino group at the phthaloyl moiety of α-methylthalidomides enhanced the activity, substituted α-methylthalidomides showed decreased stereoselectivity as compared to that of non-substituted α-methylthalidomide. The data indicates that the TNF-α production enhancing activity of thalidomide derivatives depends on both the electronic-state of substituents at the fused benzene ring and the stereochemistry of the glutarimide moiety.