10264-16-1

Basic information

• Product Name: N-butylbutanamide
• Synonyms: butanamide, N-butyl-; N-Butylbutanamide
• CAS NO: 10264-16-1
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.2267
• Mol File: 10264-16-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 235.8°C at 760 mmHg
• Flash Point: 131°C
• Density: 0.86g/cm³
• Vapor Pressure: 0.0491mmHg at 25°C
• Refractive Index: 1.426
• CAS DataBase Reference: N-butylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-butylbutanamide(10264-16-1)
• EPA Substance Registry System: N-butylbutanamide(10264-16-1)

Safety Data

• Hazardous Substances Data: 10264-16-1(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 999-33-7 N-chloro-N,N-dibutylamine 
• 111-92-2 dibutylamine 
• 107-10-8 propylamine 
• 109-73-9 N-butylamine 
• 141-75-3 butyryl chloride 
• 107-92-6 butyric acid 
• 156-54-7 sodium butyrate 
• 3858-78-4 n-butylamine hydrochloride 
• 25307-01-1 p-tolylacetic acid sodium salt 
• 114-84-1 phenylpropionic acid sodium salt 
• 1984-06-1 sodium caprylate 
• 532-32-1 sodium benzoate 
• 541-35-5 butanamide 

Downstream Products

• 107515-92-4 4-Butylaminomethyl-2-methyl-1-phenylselanyl-hexan-2-ol 
• 107515-71-9 Butyl-[3-ethyl-5-methyl-5-phenylselanylmethyl-dihydro-furan-(2E)-ylidene]-amine 
• 78455-93-3 N-butyl-N-nitroso-butyramide 

Relevant articles and documents

The synthesis of amines by the homogeneous hydrogenation of secondary and primary amides

Amides can be hydrogenated to amines using a catalyst prepared in situ from [Ru(acac)3] and 1,1,1-tris(diphenylphosphinomethyl)ethane; water is required to stabilize the catalyst and primary amines can only be formed (selectivity up to 85%) if ammonia is also present. The Royal Society of Chemistry.

One-pot reductive amination of carboxylic acids: a sustainable method for primary amine synthesis

The reductive amination of carboxylic acids is a very green, efficient and sustainable method for the production of (bio-based) amines. However, with current technology, this reaction requires two to three reaction steps. Here, we report the first (heterogeneous) catalytic system for the one-pot reductive amination of carboxylic acids to amines, with solely H2 and NH3 as the reactants. This reaction can be performed with relatively cheap ruthenium-tungsten bimetallic catalysts in the green and benign solvent cyclopentyl methyl ether (CPME). Selectivities of up to 99% for the primary amine could be achieved at high conversions. Additionally, the catalyst is recyclable and tolerant for common impurities such as water and cations (e.g. sodium carboxylate).

PRODUCTION OF AMINES

A process for the hydrogenation of carboxylic acids and/or derivatives, particularly amides, is described. The process includes reacting an acid or derivative such as an amide with a source of hydrogen in the presence of a catalyst system. The catalyst system obtainable by combining: (a) a source of ruthenium, and (b) a phosphine compound of general Formula I: (Formula I). The hydrogenation reaction is carried out in the presence of a low concentration of water or at low pressure or in the presence of a source of ammonia or the hydrogenation reaction is carried out in the absence of water or a combination of these factors is utilised. The invention also relates to the use of ammonia in the production of primary amines by hydrogenation of carboxylic acids and/or derivatives thereof or a process for the production of primary amines generally.