1026498-25-8

Basic information

• Product Name: C₂₇H₃₀F₃N₅O₄
• CAS NO: 1026498-25-8
• Molecular Weight: 545.562
• Mol File: 1026498-25-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₀F₃N₅O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₀F₃N₅O₄(1026498-25-8)
• EPA Substance Registry System: C₂₇H₃₀F₃N₅O₄(1026498-25-8)

Safety Data

• Hazardous Substances Data: 1026498-25-8(Hazardous Substances Data)

Upstream product

• 53617-35-9 4-(piperidin-4-yl)morpholine 
• 125541-20-0 tert-butyl 4-(morpholin-4-yl)piperidine-1-carboxylate 
• 1374568-27-0 C₁₈H₂₃N₅O₃ 
• 1374567-80-2 C₁₈H₂₅N₅O 
• 72220-50-9 2-[4-(trifluoromethoxy)phenoxy]acetic acid 

Relevant articles and documents

Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists

Melanin concentrating hormone (MCH) is an important mediator of energy homeostasis and plays a role in metabolic and CNS disorders. The modeling-supported design, synthesis and multi-parameter optimization (biological activity, solubility, metabolic stability, hERG) of novel quinazoline derivatives as MCHR1 antagonists are described. The in vivo proof of principle for weight loss with a lead compound from this series is exemplified. Clusters of refined hMCHR1 homology models derived from the X-ray structure of the β2-adrenergic receptor, including extracellular loops, were developed and used to guide the design.