102651-83-2Relevant articles and documents
Preparation of Methine Homologues of Aldehydes and Carboxylic Acids
Zimmermann, Birgit,Lerche, Holger,Severin, Theodor
, p. 2848 - 2858 (2007/10/02)
Dilithium salts of carboxylic acids add to glyoxal mono(dimethylhydrazone) (5) to give salts of β-hydroxy carboxylic acids.Reaction with tosyl chloride affords via decarboxylation the corresponding unsaturated aldehyde hydrazones 10 or 15, which are easily hydrolyzed and oxidized to form unsaturated carboxylic acids.By this method aldehydes and/or carboxylic acids may be extended by one methine group.Extension by three methine groups can be achieved with vinylogous monohydrazones such as 23.
