1026550-32-2Relevant articles and documents
A new method for the synthesis of silicon-and germanium-containing 2-acetylfurans and 2-acetylthiophenes
Lukevics,Ignatovich,Sleiksha,Romanov,Grinberga,Popelis,Shestakova
, p. 143 - 150 (2008/12/21)
A new method was developed for the synthesis of silicon-and germanium-containing acetylfurans and acetylthiophene by metallation of 2-acetylfuran or 2-acetylthiophene with n-BuLi at low temperature after protection of the carbonyl group with lithium N-methylpiperazide and reaction of the lithium derivative with various trialkyl-, alkylphenyl-, and cycloalkylchlorosilanes or trialkylchloro(bromo)germanes. The cytotoxic activity of the new compounds was studied, and it was established that the silicon-and germanium-containing acetylfurans and acetylthiophenes are substances with low toxicity (LD50 312->2000 mg/kg) and have low cytotoxicity toward HT-1080 and MG-22A tumor cells.